Fibrosis is defined as an excessive deposition of connective tissue components and can
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …

The discovery of the myofibroblast has opened new perspectives for the comprehension of
the biological mechanisms involved in wound healing and fibrotic diseases. In recent years …

Objectives Myofibroblasts are key effector cells in the extracellular matrix remodelling of
systemic sclerosis-associated interstitial lung disease (SSc-ILD); however, the diversity of …

Systemic autoimmune rheumatic diseases (SARDs) exhibit extensive heterogeneity in
clinical presentation, disease course, and treatment response. Therefore, precision …

A unique feature of systemic sclerosis (SSc) that distinguishes it from other fibrotic disorders
is that autoimmunity and vasculopathy characteristically precede fibrosis. Moreover, fibrosis …

Fibrosis is a pathological process characterized by excessive accumulation of connective
tissue components in an organ or tissue. Fibrosis is produced by deregulated wound …

Objectives Determine global skin transcriptome patterns of early diffuse systemic sclerosis
(SSc) and how they differ from later disease. Methods Skin biopsy RNA from 48 patients in …

Objective Clinical heterogeneity, a hallmark of systemic autoimmune diseases, impedes
early diagnosis and effective treatment, issues that may be addressed if patients could be …

Fibrosis in multiple organs is a prominent pathological finding and distinguishing hallmark of
systemic sclerosis (SSc). Findings during the past 5 years have contributed to a more …

Systemic sclerosis (SSc), also known as scleroderma, is a rare connective tissue disease
characterized by vascular and immune dysfunction, leading to fibrosis that can damage …