Quinolone and fluoroquinolone antibiotics are potent, broad-spectrum agents commonly
used to treat a range of infections. Resistance to these agents is multifactorial and can be via …

Natural products remain a critical source of medicines and drug leads. One of the most
rapidly growing superclasses of natural products is RiPPs: ribosomally synthesized and …

Transcription of highly expressed genes has been shown to occur in stochastic bursts. But
the origin of such ubiquitous phenomenon has not been understood. Here, we present the …

How genomes are organized within cells and how the 3D architecture of a genome
influences cellular functions are significant questions in biology. A bacterial genomic DNA …

Nucleoid-associated proteins (NAPs) are global regulators of gene expression in
Escherichia coli, which affect DNA conformation by bending, wrapping and bridging the …

Many bacterial cellular processes interact intimately with the chromosome. Such interplay is
the major driving force of genome structure or organization. Interactions take place at …

The role of nonlinear DNA in replication, recombination, and transcription has become
evident in recent years. Although several studies have predicted and characterized …

Transcription has the capacity to mechanically modify DNA topology, DNA structure and
nucleosome arrangement. Resulting from ongoing transcription, these modifications in turn …

DNA supercoiling is a biophysical feature of the double helix with a pivotal role in biological
processes. However, understanding of DNA supercoiling in the chromatin remains limited …

Background The processes of DNA supercoiling and transcription are interdependent
because the movement of a transcription elongation complex simultaneously induces under …