The immunology of rheumatoid arthritis
CM Weyand, JJ Goronzy - Nature immunology, 2021 - nature.com
The immunopathogenesis of rheumatoid arthritis (RA) spans decades, beginning with the
production of autoantibodies against post-translationally modified proteins (checkpoint 1) …
production of autoantibodies against post-translationally modified proteins (checkpoint 1) …
Promising therapeutic targets for treatment of rheumatoid arthritis
Rheumatoid arthritis (RA) is a systemic poly-articular chronic autoimmune joint disease that
mainly damages the hands and feet, which affects 0.5% to 1.0% of the population …
mainly damages the hands and feet, which affects 0.5% to 1.0% of the population …
Development of an epigenetic clock resistant to changes in immune cell composition
Epigenetic clocks are age predictors that use machine-learning models trained on DNA CpG
methylation values to predict chronological or biological age. Increases in predicted …
methylation values to predict chronological or biological age. Increases in predicted …
Functional genomics analysis identifies T and NK cell activation as a driver of epigenetic clock progression
Background Epigenetic clocks use DNA methylation (DNAm) levels of specific sets of CpG
dinucleotides to accurately predict individual chronological age. A popular application of …
dinucleotides to accurately predict individual chronological age. A popular application of …
Molecular mechanisms of immunosenescene and inflammaging: relevance to the immunopathogenesis and treatment of multiple sclerosis
O Perdaens, V Van Pesch - Frontiers in neurology, 2022 - frontiersin.org
Aging is characterized, amongst other features, by a complex process of cellular
senescence involving both innate and adaptive immunity, called immunosenescence and …
senescence involving both innate and adaptive immunity, called immunosenescence and …
[HTML][HTML] Trained immunity and inflammation in rheumatic diseases
Background Rheumatic diseases include a variety of autoimmune and autoinflammatory
conditions that are characterised by musculoskeletal involvement and systemic disease …
conditions that are characterised by musculoskeletal involvement and systemic disease …
Development of a novel epigenetic clock resistant to changes in immune cell composition
Epigenetic clocks are age predictors that use machine-learning models trained on DNA CpG
methylation values to predict chronological or biological age. Increases in predicted …
methylation values to predict chronological or biological age. Increases in predicted …
DNA methylation signatures of response to conventional synthetic and biologic disease-modifying antirheumatic drugs (DMARDs) in rheumatoid arthritis
SS Wang, MJ Lewis, C Pitzalis - Biomedicines, 2023 - mdpi.com
Rheumatoid arthritis (RA) is a complex condition that displays heterogeneity in disease
severity and response to standard treatments between patients. Failure rates for …
severity and response to standard treatments between patients. Failure rates for …
Prediction of the progression of undifferentiated arthritis to rheumatoid arthritis using DNA methylation profiling
C de la Calle‐Fabregat… - Arthritis & …, 2021 - Wiley Online Library
Objective The term “undifferentiated arthritis (UA)” is used to refer to all cases of arthritis that
do not fit a specific diagnosis. A significant percentage of UA patients progress to …
do not fit a specific diagnosis. A significant percentage of UA patients progress to …
Methylation of T and B Lymphocytes in Autoimmune Rheumatic Diseases
T Deng, Z Wang, Q Geng, Z Wang, Y Jiao… - Clinical Reviews in …, 2024 - Springer
The role of abnormal epigenetic modifications, particularly DNA methylation, in the
pathogenesis of autoimmune rheumatic diseases (ARDs) has garnered increasing attention …
pathogenesis of autoimmune rheumatic diseases (ARDs) has garnered increasing attention …