Marine natural products

JW Blunt, BR Copp, RA Keyzers, MHG Munro… - Natural product …, 2017 - pubs.rsc.org
Covering: 2015. Previous review: Nat. Prod. Rep., 2016, 33, 382–431 This review covers the
literature published in 2015 for marine natural products (MNPs), with 1220 citations (792 for …

Feeling nature's PAINS: natural products, natural product drugs, and pan assay interference compounds (PAINS)

JB Baell - Journal of natural products, 2016 - ACS Publications
We have previously reported on classes of compounds that can interfere with bioassays via
a number of different mechanisms and termed such compounds Pan Assay INterference …

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease

S Rangaraju, EB Dammer, SA Raza… - Molecular …, 2018 - Springer
Background Disease-associated-microglia (DAM) represent transcriptionally-distinct and
neurodegeneration-specific microglial profiles with unclear significance in Alzheimer's …

Cyclic peptides in pipeline: what future for these great molecules?

L Costa, E Sousa, C Fernandes - Pharmaceuticals, 2023 - mdpi.com
Cyclic peptides are molecules that are already used as drugs in therapies approved for
various pharmacological activities, for example, as antibiotics, antifungals, anticancer, and …

Potassium channels in Parkinson's disease: potential roles in its pathogenesis and innovative molecular targets for treatment

X Chen, Y Feng, RJ Quinn, DL Pountney… - Pharmacological …, 2023 - ASPET
Parkinson's disease (PD) is a neurodegenerative disorder characterized by selective loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the midbrain …

[PDF][PDF] Natural product reports

JW Blunt, BR Copp, RA Keyzers, MH Munroa… - Nat Prod Rep, 2016 - academia.edu
This review covers the literature published in 2015 for marine natural products (MNPs), with
1220 citations (792 for the period January to December 2015) referring to compounds …

Sea anemones: Quiet achievers in the field of peptide toxins

P J. Prentis, A Pavasovic, R S. Norton - Toxins, 2018 - mdpi.com
Sea anemones have been understudied as a source of peptide and protein toxins, with
relatively few examined as a source of new pharmacological tools or therapeutic leads. This …

The secret life of ion channels: Kv1. 3 potassium channels and proliferation

MT Pérez-García, P Cidad… - American Journal of …, 2018 - journals.physiology.org
Kv1. 3 channels are involved in the switch to proliferation of normally quiescent cells, being
implicated in the control of cell cycle in many different cell types and in many different ways …

The voltage-gated potassium channel KV1. 3 as a therapeutic target for venom-derived peptides

G Tajti, DCC Wai, G Panyi, RS Norton - Biochemical pharmacology, 2020 - Elsevier
The voltage-gated potassium channel KV 1.3 is a well-established therapeutic target for a
range of autoimmune diseases, in addition to being the site of action of many venom-derived …

The voltage-gated potassium channel Kv1. 3 is a promising multitherapeutic target against human pathologies

M Perez-Verdaguer, J Capera… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: The voltage-dependent potassium channel Kv1. 3 is mainly present in the
nervous and immune systems. In leukocytes, Kv1. 3 fine-tunes the activation and …