Magnetic particle imaging: current applications in biomedical research

N Talebloo, M Gudi, N Robertson… - Journal of Magnetic …, 2020 - Wiley Online Library
Magnetic particle imaging (MPI) is a new imaging modality with the potential for high‐
resolution imaging while retaining the noninvasive nature of other current modalities such as …

[HTML][HTML] Magnetic particle imaging of islet transplantation in the liver and under the kidney capsule in mouse models

P Wang, PW Goodwill, P Pandit, J Gaudet… - … Imaging in Medicine …, 2018 - ncbi.nlm.nih.gov
Background Islet transplantation (Tx) represents the most promising therapy to restore
normoglycemia in type 1 diabetes (T1D) patients to date. As significant islet loss has been …

[HTML][HTML] RNA aptamers specific for transmembrane p24 trafficking protein 6 and Clusterin for the targeted delivery of imaging reagents and RNA therapeutics to human …

D Van Simaeys, A De La Fuente, S Zilio, A Zoso… - Nature …, 2022 - nature.com
The ability to detect and target β cells in vivo can substantially refine how diabetes is studied
and treated. However, the lack of specific probes still hampers a precise characterization of …

Artificial intelligence analysis of magnetic particle imaging for islet transplantation in a mouse model

H Hayat, A Sun, H Hayat, S Liu, N Talebloo… - Molecular imaging and …, 2021 - Springer
Purpose Current approaches to quantification of magnetic particle imaging (MPI) for cell-
based therapy are thwarted by the lack of reliable, standardized methods of segmenting the …

[HTML][HTML] Transplanted adipose-derived stem cells can be short-lived yet accelerate healing of acid-burn skin wounds: a multimodal imaging study

G Muhammad, J Xu, JWM Bulte, A Jablonska… - Scientific reports, 2017 - nature.com
The incidence of accidental and intentional acid skin burns is rising. Current treatment
strategies are mostly inadequate, leaving victims disfigured and without treatment options …

Phase-changing citrate macromolecule combats oxidative pancreatic islet damage, enables islet engraftment and function in the omentum

JA Burke, Y Zhu, X Zhang, PD Rios, I Joshi… - Science …, 2024 - science.org
Clinical outcomes for total-pancreatectomy followed by intraportal islet autotransplantation
(TP-IAT) to treat chronic pancreatitis (CP) are suboptimal due to pancreas inflammation …

[HTML][HTML] Beta cell imaging—From pre-clinical validation to first in man testing

S Demine, ML Schulte, PR Territo… - International journal of …, 2020 - mdpi.com
There are presently no reliable ways to quantify human pancreatic beta cell mass (BCM) in
vivo, which prevents an accurate understanding of the progressive beta cell loss in diabetes …

Monitoring β-cell survival after intrahepatic islet transplantation using dynamic exendin PET imaging: a proof-of-concept study in individuals with type 1 diabetes

TJP Jansen, M Buitinga, M Boss, MF Nijhoff, M Brom… - Diabetes, 2023 - Am Diabetes Assoc
Intrahepatic transplantation of islets of Langerhans (ITx) is a treatment option for individuals
with complicated type 1 diabetes and profoundly unstable glycemic control, but its …

Protection of pancreatic islets using theranostic silencing nanoparticles in a baboon model of islet transplantation

T Pomposelli, P Wang, K Takeuchi, K Miyake… - Diabetes, 2020 - Am Diabetes Assoc
The long-term success of pancreatic islet transplantation (Tx) as a cure for type 1 diabetes
remains limited. Islet loss after Tx related to apoptosis, inflammation, and other factors …

[HTML][HTML] Islet transplantation

L Piemonti - 2015 - europepmc.org
Transplanting islets of Langerhans consists of implantation in the recipient's hepatic portal
system of endocrine pancreatic tissue, with a variable degree of purification. The field of islet …