[HTML][HTML] Targeting the hippo pathway and cancer through the TEAD family of transcription factors
JK Holden, CN Cunningham - Cancers, 2018 - mdpi.com
The Hippo pathway is a critical transcriptional signaling pathway that regulates cell growth,
proliferation and organ development. The transcriptional enhanced associate domain …
proliferation and organ development. The transcriptional enhanced associate domain …
Hippo pathway inhibition by blocking the YAP/TAZ–TEAD interface: a patent review
JJ Crawford, SM Bronner, JR Zbieg - Expert opinion on therapeutic …, 2018 - Taylor & Francis
ABSTRACT Introduction: The Hippo pathway represents a new and intriguing opportunity for
the treatment of cancer. Activation or overexpression of Yes-associated protein (YAP) or …
the treatment of cancer. Activation or overexpression of Yes-associated protein (YAP) or …
[HTML][HTML] Small molecule dysregulation of TEAD lipidation induces a dominant-negative inhibition of hippo pathway signaling
JK Holden, JJ Crawford, CL Noland, S Schmidt… - Cell reports, 2020 - cell.com
The transcriptional enhanced associate domain (TEAD) family of transcription factors serves
as the receptors for the downstream effectors of the Hippo pathway, YAP and TAZ, to …
as the receptors for the downstream effectors of the Hippo pathway, YAP and TAZ, to …
[HTML][HTML] Leveraging Hot Spots of TEAD–Coregulator Interactions in the Design of Direct Small Molecule Protein-Protein Interaction Disruptors Targeting Hippo …
The Hippo signaling pathway is a highly conserved pathway that plays important roles in the
regulation of cell proliferation and apoptosis. Transcription factors TEAD1-4 and …
regulation of cell proliferation and apoptosis. Transcription factors TEAD1-4 and …
N‐terminal β‐strand in YAP is critical for stronger binding to scalloped relative to TEAD transcription factor
F Bokhovchuk, Y Mesrouze, M Meyerhofer… - Protein …, 2023 - Wiley Online Library
The yes‐associated protein (YAP) regulates the transcriptional activity of the TEAD
transcription factors that are key in the control of organ morphogenesis. YAP interacts with …
transcription factors that are key in the control of organ morphogenesis. YAP interacts with …
An Early Association between the α-Helix of the TEAD Binding Domain of YAP and TEAD Drives the Formation of the YAP: TEAD Complex
F Bokhovchuk, Y Mesrouze, M Meyerhofer… - Biochemistry, 2020 - ACS Publications
The Hippo pathway is an evolutionarily conserved signaling pathway that is involved in the
control of organ size and development. The TEAD transcription factors are the most …
control of organ size and development. The TEAD transcription factors are the most …
[HTML][HTML] Late metabolic precursors for selective aromatic residue labeling
J Schörghuber, L Geist, G Platzer, M Feichtinger… - Journal of Biomolecular …, 2018 - Springer
In recent years, we developed a toolbox of heavy isotope containing compounds, which
serve as metabolic amino acid precursors in the E. coli-based overexpression of aromatic …
serve as metabolic amino acid precursors in the E. coli-based overexpression of aromatic …
[HTML][HTML] Long-range structural preformation in yes-associated protein precedes encounter complex formation with TEAD
M Feichtinger, A Beier, M Migotti, M Schmid… - Iscience, 2022 - cell.com
Yes-associated protein (YAP) is a partly intrinsically disordered protein (IDP) that plays a
major role as the downstream element of the Hippo pathway. Although the structures of the …
major role as the downstream element of the Hippo pathway. Although the structures of the …
Study of the TEAD‐binding domain of the YAP protein from animal species
Y Mesrouze, F Bokhovchuk, M Meyerhofer… - Protein …, 2021 - Wiley Online Library
The Hippo signaling pathway, which plays a central role in the control of organ size in
animals, is well conserved in metazoans. The most downstream elements of this pathway …
animals, is well conserved in metazoans. The most downstream elements of this pathway …