In order to optimize a lead molecule for further development, bioisosteric replacements are
generally adopted as one of the strategies. Silicon appears to be the right choice as a …

Unnatural α-amino acids form a family of essential molecules used for, among other
applications, the synthesis of modified peptides, to improve resistance to proteolytic enzyme …

Because of the problems associated with opioids, drug discovery efforts have been
employed to develop opioids with reduced side effects using approaches such as biased …

The increasing incidence and rapid spread of bacterial resistance to conventional antibiotics
are a serious global threat to public health, highlighting the need to develop new …

Many synthetic peptides have been developed for diagnosis and therapy of human cancers
based on their ability to target specific receptors on cancer cell surface or to penetrate the …

Introduction: Neurotensin is a gut-brain peptide hormone, a 13 amino acid neuropeptide
found in the central nervous system and in the GI tract. The neurotensinergic system is …

The modulatory interactions between neurotensin (NT) and the dopaminergic
neurotransmitter system in the brain suggest that NT may be associated with the progression …

The neurotensin receptors are attractive targets for the development of new analgesic
compounds. They represent potential alternatives or adjuvants to opioids. Herein, we report …

Pain is a prevalent complex medical problem, characterized by physically debilitating and
mentally destabilizing conditions. Current pain therapeutics mainly include non-steroidal …

A practical and efficient ligand-free MnO 2 mediated sequential oxidation and olefination
has been developed for the facile synthesis of a broad range of unsaturated N …