Chalcone derivatives are considered valuable species because they possess a
ketoethylenic moiety, CO–CH═ CH–. Due to the presence of a reactive α, β-unsaturated …

With some indoles and azaindoles being successfully developed as anticancer drugs, the
design and synthesis of indole and azaindole derivatives with remarkable antitumor activity …

Tuberculosis (TB) is a lift-threatening chronic deadliest infectious disease caused
predominantly by Mycobacterium tuberculosis (MTB) which affects primarily the lungs …

Rhodanines are accepted as advantaged heterocycles in medicinal chemistry as one of the
4-thiazolidinones subtypes. The aim of this paper is to analyze the features of rhodanine and …

Most of the anti-inflammatory drugs in clinical practice are becoming outdated owing to their
potential side and adverse effects. These are found to be highly unsafe for long term use …

Inflammation is a most complex pathological process that gives birth to different diseases.
Different inflammatory mediators are released during an inflammation responsible for acute …

Breast cancer (BC) is a devastating disease in female around the world causing significant
health care burden in both developed and developing countries. In many cases BC has …

A systematic, rational search for chalcone derivatives with multifunctional behavior has been
carried out, with the support of a computer-assisted protocol (CADMA-Chem). A total of 568 …

Introduction: Chalcones are attractive to synthetic chemists because they are easy to
prepare, have a large number of replaceable hydrogens, thereby having significant …

To evaluate the role of COX-2 and 5-LOX as dual inhibitors in controlling the cancer cell
proliferation, a set of two series having 42 compounds of 1, 2, 3-Tethered Indole-3 …