[HTML][HTML] Artificial intelligence in pharmaceutical technology and drug delivery design
Artificial intelligence (AI) has emerged as a powerful tool that harnesses anthropomorphic
knowledge and provides expedited solutions to complex challenges. Remarkable …
knowledge and provides expedited solutions to complex challenges. Remarkable …
Concepts of artificial intelligence for computer-assisted drug discovery
X Yang, Y Wang, R Byrne, G Schneider… - Chemical …, 2019 - ACS Publications
Artificial intelligence (AI), and, in particular, deep learning as a subcategory of AI, provides
opportunities for the discovery and development of innovative drugs. Various machine …
opportunities for the discovery and development of innovative drugs. Various machine …
[HTML][HTML] The blood-brain barrier: an engineering perspective
It has been more than 100 years since Paul Ehrlich reported that various water-soluble dyes
injected into the circulation did not enter the brain. Since Ehrlich's first experiments, only a …
injected into the circulation did not enter the brain. Since Ehrlich's first experiments, only a …
Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers
I Hubatsch, EGE Ragnarsson, P Artursson - Nature protocols, 2007 - nature.com
Permeability coefficients across monolayers of the human colon carcinoma cell line Caco-2,
cultured on permeable supports, are commonly used to predict the absorption of orally …
cultured on permeable supports, are commonly used to predict the absorption of orally …
Coexistence of passive and carrier-mediated processes in drug transport
K Sugano, M Kansy, P Artursson, A Avdeef… - Nature reviews Drug …, 2010 - nature.com
The permeability of biological membranes is one of the most important determinants of the
pharmacokinetic processes of a drug. Although it is often accepted that many drug …
pharmacokinetic processes of a drug. Although it is often accepted that many drug …
[引用][C] Absorption and drug development: solubility, permeability, and charge state
A Avdeef - 2012 - books.google.com
Explains how to perform and analyze the results of the latest physicochemical methods With
this book as their guide, readers have access to all the current information needed to …
this book as their guide, readers have access to all the current information needed to …
Early pharmaceutical profiling to predict oral drug absorption: current status and unmet needs
CAS Bergström, R Holm, SA Jørgensen… - European Journal of …, 2014 - Elsevier
Preformulation measurements are used to estimate the fraction absorbed in vivo for orally
administered compounds and thereby allow an early evaluation of the need for enabling …
administered compounds and thereby allow an early evaluation of the need for enabling …
ADME properties evaluation in drug discovery: prediction of Caco-2 cell permeability using a combination of NSGA-II and boosting
The Caco-2 cell monolayer model is a popular surrogate in predicting the in vitro human
intestinal permeability of a drug due to its morphological and functional similarity with human …
intestinal permeability of a drug due to its morphological and functional similarity with human …
A novel design of artificial membrane for improving the PAMPA model
X Chen, A Murawski, K Patel, CL Crespi… - Pharmaceutical …, 2008 - Springer
Purpose Since the first demonstration of PAMPA, the artificial membrane has been
traditionally prepared by impregnating a porous filter with a solution of lipid mixture. While …
traditionally prepared by impregnating a porous filter with a solution of lipid mixture. While …
The rise of PAMPA
A Avdeef - Expert opinion on drug metabolism & toxicology, 2005 - Taylor & Francis
The parallel artificial membrane permeability assay (PAMPA), as a passive-permeability
screen, is a possible low-cost alternative to cellular models for the earliest ADME primary …
screen, is a possible low-cost alternative to cellular models for the earliest ADME primary …