Development and effects of influenza antiviral drugs

H Yin, N Jiang, W Shi, X Chi, S Liu, JL Chen, S Wang - Molecules, 2021 - mdpi.com
Influenza virus is a highly contagious zoonotic respiratory disease that causes seasonal
outbreaks each year and unpredictable pandemics occasionally with high morbidity and …

A chimeric haemagglutinin-based universal influenza virus vaccine boosts human cellular immune responses directed towards the conserved haemagglutinin stalk …

CM Bliss, R Nachbagauer, C Mariottini, F Cuevas… - …, 2024 - thelancet.com
Background The development of a universal influenza virus vaccine, to protect against both
seasonal and pandemic influenza A viruses, is a long-standing public health goal. The …

Identification and characterization of swine influenza virus h1n1 variants generated in vaccinated and nonvaccinated, challenged pigs

Á López-Valiñas, M Sisteré-Oró, S López-Serrano… - Viruses, 2021 - mdpi.com
Influenza viruses represent a continuous threat to both animal and human health. The 2009
H1N1 A influenza pandemic highlighted the importance of a swine host in the adaptation of …

Genetic diversification patterns in swine influenza A virus (H1N2) in vaccinated and nonvaccinated animals

Á López-Valiñas, M Valle, M Pérez, A Darji… - Frontiers in cellular …, 2023 - frontiersin.org
Influenza A viruses (IAVs) are characterized by having a segmented genome, low
proofreading polymerases, and a wide host range. Consequently, IAVs are constantly …

Hydrophobic mismatch controls the mode of membrane-mediated interactions of transmembrane peptides

OV Kondrashov, PI Kuzmin, SA Akimov - Membranes, 2022 - mdpi.com
Various cellular processes require the concerted cooperative action of proteins. The
possibility for such synchronization implies the occurrence of specific long-range …

Temporal and gene reassortment analysis of influenza C virus outbreaks in Hong Kong, SAR, China

RS Daniels, M Galiano, B Ermetal, J Kwong… - Journal of …, 2022 - Am Soc Microbiol
ABSTRACT From 2014 to week 07/2020 the Centre for Health Protection in Hong Kong
conducted screening for influenza C virus (ICV). A retrospective analysis of ICV detections to …

Molecular Mechanisms behind Conformational Transitions of the Influenza Virus Hemagglutinin Membrane Anchor

M Michalski, P Setny - The Journal of Physical Chemistry B, 2023 - ACS Publications
Membrane fusion is a fundamental process that is exploited by enveloped viruses to enter
host cells. In the case of the influenza virus, fusion is facilitated by the trimeric viral …

[HTML][HTML] Unique properties of Coronaviridae single-pass transmembrane domain regions as an adaptation to diverse membrane systems

S Kubiszewski-Jakubiak, R Worch - Virology, 2022 - Elsevier
Enveloped viruses such as Coronaviridae (CoV) enter the host cell by fusing the viral
envelope directly with the plasma membrane (PM) or with the membrane of the endosome …

[HTML][HTML] High expression of the classical swine fever virus (CSFV) envelope protein E2 by a single amino acid mutation and its embedded in the pseudorabies virus …

Y Sun, K Liu, T Yun, Z Ni, Y Zhu, L Chen, H Bao, W Ye… - Virus Research, 2023 - Elsevier
Pseudorabies (PR) and classical swine fever (CSF) are economically important infectious
diseases in pigs. Most pig farms in China are vaccinated against these two diseases. Gene …

Evolution of swine influenza virus associated with vaccination

Á López Valiñas - 2022 - ddd.uab.cat
El virus de la Influenza A (IAV) és un patogen mundialment distribuït que pot infectar a una
varietat d'espècies d'aus i de mamífers, inclosos porcs i humans. Es tracta d'un virus d'ARN …