The prefrontal cortex plays an important role in shaping cognition and behavior. Many
studies have shown that medial prefrontal cortex (mPFC) plays a key role in seeking …

Development of pharmacotherapy to reduce relapse rates is one of the biggest challenges
in drug addiction research. The enduring nature of relapse suggests that it is maintained by …

Cues associated with rewards acquire the ability to engage the same brain systems as
rewards themselves. However, reward cues have multiple properties. For example, they not …

One of the major functions of the orbitofrontal cortex (OFC) is to promote flexible motivated
behavior. It is no surprise, therefore, that recent work has demonstrated a prominent impact …

Ventral tegmental area (VTA) dopamine neurons are crucial for appetitive responses to
Pavlovian cues, including cue-induced reinstatement of drug seeking. However, it is …

Drug addiction is a chronic relapsing disorder, and a significant amount of research has
been devoted to understand the factors that contribute to the development, loss of control …

Background Comorbidity of anxiety disorders, stressor-and trauma-related disorders, and
substance use disorders is extremely common. Moreover, therapies that reduce pathological …

Conditioned drug craving and withdrawal elicited by cues paired with drug use or acute
withdrawal are among the many factors contributing to compulsive drug taking …

Beyond their rapid rewarding effects, drugs of abuse can durably alter an individual's
response to their environment as illustrated by the compulsive drug seeking and risk of …

Cocaine stimuli often trigger relapse of drug‐taking, even following periods of prolonged
abstinence. Here, electrophysiological recordings were made in rats (n= 29) to determine …