Hydrogen peroxide, the nonradical 2-electron reduction product of oxygen, is a normal
aerobic metabolite occurring at about 10 nm intracellular concentration. In liver, it is …

Significance: Fluorescent protein sensors have revitalized the field of redox biology by
revolutionizing the study of redox processes in living cells and organisms. Recent Advances …

Mitochondrial reactive oxygen species (ROS) production is a tightly regulated redox signal
that transmits information from the organelle to the cell. Other mitochondrial signals, such as …

Abstract Hydrogen peroxide (H 2 O 2) acts as a signaling messenger by oxidatively
modifying distinct cysteinyl thiols in distinct target proteins. However, it remains unclear how …

Ascorbate (AscH−) functions as a versatile reducing agent. At pharmacological doses (P-
AscH−;[plasma AscH−]≥≈ 20 mM), achievable through intravenous delivery, oxidation of P …

Abstract Hydrogen peroxide (H2O2) acts as a signaling messenger by triggering the
reversible oxidation of redox-regulated proteins. It remains unclear how proteins can be …

Irreversible oxidation of Cys residues to sulfinic/sulfonic forms typically impairs protein
function. We found that persulfidation (CysSSH) protects Cys from irreversible oxidative loss …

Genetically encoded probes based on the H2O2-sensing proteins OxyR and Orp1 have
greatly increased the ability to detect elevated H2O2 levels in stimulated or stressed cells …

Summary Hydrogen peroxide (H2O2) is ubiquitous in cells and at the centre of
developmental programmes and environmental responses. Its chemistry in cells makes …

The purpose of the current study was to investigate the effect of the recently synthesized
mitochondrially-targeted H 2 S donor, AP39 [(10-oxo-10-(4-(3-thioxo-3H-1, 2-dithiol-5yl) …