Objectives: The objectives of this research were:(1) to heighten awareness of Gaucher
disease (GD), a rare lysosomal storage disorder with highly heterogeneous patterns of …

Gaucher disease is the commonest lysosomal storage disease seen in India and worldwide.
It should be considered in any child or adult with an unexplained splenohepatomegaly and …

Gaucher disease (GD), the most prevalent lysosomal storage disorder, affects multiple organ
systems. Patients with non-neuronopathic (type 1) GD, the most common form of GD …

Enzyme replacement therapy (ERT) is effective for the treatment of the systemic
manifestations of Gaucher disease (GD) and can have a significant impact on skeletal …

Background GD1-DS3 is an integrated assessment of type 1 Gaucher disease (GD1) burden
based on bone, hematologic and visceral domains. We investigated this disease severity …

BACKGROUND: Earlier results highlighted hyperferritinemia during type-1 Gaucher disease
(GD), but its potential mechanisms and long-term progression remained unexamined …

The introduction of disease-specific therapy for patients with type I Gaucher disease (GD1)
was a revolution in the management of patients, but not without cost. Thus, the management …

Osteoporosis is commonly associated with menopause and ageing. It can, however, also be
caused by diseases, lifestyle, genetic diseases, drug therapies and other therapeutic …

Bones' strength is achieved and maintained through adaptation to load bearing. The role of
the protein kinase PKCα in this process has not been previously reported. However, we …

Gaucher disease (GD) is an inherited lysosomal storage disorder affecting multiple organs.
Non-neuronopathic GD, the most common form, can present with hepatosplenomegaly …