Protein molecules naturally emit streams of information-rich signals in the language of
hydrogen exchange concerning the intimate details of their stability, dynamics, function …

Functional regulation of ligand-activated receptors is driven by alterations in the
conformational dynamics of the protein upon ligand binding. Differential hydrogen/deuterium …

Hydrogen/deuterium exchange mass spectrometry (HDX-MS) is an established method for
the interrogation of protein conformation and dynamics. While the data analysis challenge of …

Proteins that undergo cooperative unfolding events display EX1 kinetic signatures in
hydrogen exchange mass spectra. The hallmark bimodal isotope pattern observed for EX1 …

Noisy and overlapped mass spectrometry data hinder the sequence coverage that can be
obtained from hydrogen deuterium exchange analysis, and places a limit on the complexity …

Abstract A Microsoft Excel utility, HX-Express, that significantly accelerates the analysis of
hydrogen exchange mass spectrometry data is described. HX-Express generates deuterium …

Assessing the functional outcome of protein interactions in structural terms is a goal of
structural biology, however most techniques have a limited capacity for making structure …

The addition of mass spectrometry (MS) analysis to the hydrogen exchange (HX) proteolytic
fragmentation experiment extends powerful HX methodology to the study of large …

Hydrogen/deuterium exchange coupled to mass spectrometry is an excellent technique to
study protein structure changes and interactions, especially in cases where traditional high …

Two‐component systems mediate bacterial signal transduction, employing a membrane
sensor kinase and a cytoplasmic response regulator (RR). Environmental sensing is …