Stereochemistry in the disorder–order continuum of protein interactions

EA Newcombe, AD Due, A Sottini, S Elkjær, FF Theisen… - Nature, 2024 - nature.com
Intrinsically disordered proteins can bind via the formation of highly disordered protein
complexes without the formation of three-dimensional structure. Most naturally occurring …

Assessment of machine‐learning predictions for the Mediator complex subunit MED25 ACID domain interactions with transactivation domains

D Monté, Z Lens, F Dewitte, V Villeret, A Verger - FEBS letters, 2024 - Wiley Online Library
The human Mediator complex subunit MED25 binds transactivation domains (TADs) present
in various cellular and viral proteins using two binding interfaces, named H1 and H2, which …

The molecular basis of pine wilt disease resistance in Pinus massoniana

J Wang, S Cai, L Zeng, J Tong, D Hang, X Zhang… - bioRxiv, 2024 - biorxiv.org
Pine wilt disease (PWD), caused by the pine wood nematode (PWN) Bursaphelenchus
xylophilus, results in significant economic and ecological damage to Pinus forests and …

An integrative characterisation of proline cis and trans conformers in a disordered peptide

AJ Pettitt, VK Shukla, AM Figueiredo, LS Newton… - bioRxiv, 2024 - biorxiv.org
Intrinsically disordered proteins (IDPs) often contain proline residues, which undergo
cis/trans isomerisation. While molecular dynamics (MD) simulations have the potential to …

Assessment of machine-learning predictions for MED25 ACID domain interactions with transactivation domains

D Monte, Z Lens, F Dewitte, V Villeret, A Verger - bioRxiv, 2023 - biorxiv.org
Human Mediator complex subunit MED25 binds transactivation domains (TADs) present in
various cellular and viral proteins using two binding interfaces found on opposite sides of its …

Biophysical characterisation of ORF6 from SARS-CoV-2

AJ Pettitt - 2024 - discovery.ucl.ac.uk
Open reading frame 6 (ORF6) from severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) plays an important role in suppressing the immune response in coronavirus disease …

[PDF][PDF] Analyse du paysage d'épissage alternatif d'Arabidopsis thaliana

T Barff - 2024 - depot-e.uqtr.ca
Les végétaux sont des organismes sessiles qui doivent s' adapter à divers changements
environnementaux pour survivre. Pour ce faire, ils disposent de nombreux mécanismes …