Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for type II diabetes
The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
Islet amyloid polypeptide, islet amyloid, and diabetes mellitus
P Westermark, A Andersson… - Physiological …, 2011 - journals.physiology.org
Islet amyloid polypeptide (IAPP, or amylin) is one of the major secretory products of β-cells of
the pancreatic islets of Langerhans. It is a regulatory peptide with putative function both …
the pancreatic islets of Langerhans. It is a regulatory peptide with putative function both …
Type 2 diabetes as a protein misfolding disease
A Mukherjee, D Morales-Scheihing, PC Butler… - Trends in molecular …, 2015 - cell.com
Type 2 diabetes (T2D) is a highly prevalent and chronic metabolic disorder. Recent
evidence suggests that formation of toxic aggregates of the islet amyloid polypeptide (IAPP) …
evidence suggests that formation of toxic aggregates of the islet amyloid polypeptide (IAPP) …
Effects of in vivo conditions on amyloid aggregation
One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …
govern protein misfolding and aggregation, which is a highly complex process that is …
[HTML][HTML] Toxic species in amyloid disorders: Oligomers or mature fibrils
Protein aggregation is the hallmark of several neurodegenerative disorders. These protein
aggregation (fibrillization) disorders are also known as amyloid disorders. The mechanism …
aggregation (fibrillization) disorders are also known as amyloid disorders. The mechanism …
Amylin deposition in the brain: a second amyloid in Alzheimer disease?
K Jackson, GA Barisone, E Diaz, L Jin… - Annals of …, 2013 - Wiley Online Library
Objective Hyperamylinemia, a common pancreatic disorder in obese and insulin‐resistant
patients, is known to cause amylin oligomerization and cytotoxicity in pancreatic islets …
patients, is known to cause amylin oligomerization and cytotoxicity in pancreatic islets …
Islet amyloid polypeptide: structure, function, and pathophysiology
R Akter, P Cao, H Noor, Z Ridgway… - Journal of diabetes …, 2016 - Wiley Online Library
The hormone islet amyloid polypeptide (IAPP, or amylin) plays a role in glucose
homeostasis but aggregates to form islet amyloid in type‐2 diabetes. Islet amyloid formation …
homeostasis but aggregates to form islet amyloid in type‐2 diabetes. Islet amyloid formation …
Islet β cell mass in diabetes and how it relates to function, birth, and death
GC Weir, S Bonner‐Weir - Annals of the New York Academy of …, 2013 - Wiley Online Library
In type 1 diabetes (T1D) β cell mass is markedly reduced by autoimmunity. Type 2 diabetes
(T2D) results from inadequate β cell mass and function that can no longer compensate for …
(T2D) results from inadequate β cell mass and function that can no longer compensate for …
[HTML][HTML] β-cell loss and β-cell apoptosis in human type 2 diabetes are related to islet amyloid deposition
CA Jurgens, MN Toukatly, CL Fligner… - The American journal of …, 2011 - Elsevier
Amyloid deposition and reduced β-cell mass are pathological hallmarks of the pancreatic
islet in type 2 diabetes; however, whether the extent of amyloid deposition is associated with …
islet in type 2 diabetes; however, whether the extent of amyloid deposition is associated with …
The molecular mechanisms of pancreatic β-cell glucotoxicity: recent findings and future research directions
M Bensellam, DR Laybutt, JC Jonas - Molecular and cellular endocrinology, 2012 - Elsevier
It is well established that regular physiological stimulation by glucose plays a crucial role in
the maintenance of the β-cell differentiated phenotype. In contrast, prolonged or repeated …
the maintenance of the β-cell differentiated phenotype. In contrast, prolonged or repeated …