Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Vitamin A (all-trans retinol) and its active metabolites, collectively called retinoids, exert
potent effects on stem cell differentiation and thus, the formation of the entire organism, in …

Cerebral visual impairment (CVI) is a major cause of low vision in children due to
impairment in projection and/or interpretation of the visual input in the brain. Although …

Cancer cell heterogeneity is a major driver of therapy resistance. To characterize resistant
cells and their vulnerabilities, we studied the PLZF-RARA variant of acute promyelocytic …

Polycomb proteins play an essential role in maintaining the repression of developmental
genes in self-renewing embryonic stem cells. The exact mechanism allowing the …

Loss of HOXA5 expression occurs frequently in breast cancer and correlates with higher
pathological grade and poorer disease outcome. However, how HOX proteins drive …

Vitamin A (VA) is an essential micronutrient. Numerous studies have confirmed that VA
deficiency (VAD) leads to a decline in learning and memory function. Our previous studies …

Epigenetics is “the branch of biology which studies the causal interactions between genes
and their products which bring the phenotype into being” as defined by Conrad Waddington …

Tightly-regulated levels of retinoic acid (RA) are critical for promoting normal vertebrate
development. The extensive history of research on RA has shown that its proper regulation …

Identification of target genes that mediate required functions downstream of transcription
factors is hampered by the large number of genes whose expression changes when the …