The approach to a patient with erythrocytosis is greatly simplified by assessing the clonality
of the process upfront. In this regard, there has been a dramatic shift toward genetic testing …

A major driver of the pathophysiology of sickle cell disease (SCD) is polymerization of
deoxygenated haemoglobin S (HbS), which leads to sickling and destruction of red blood …

Primary familial and congenital polycythemia (PFCP) is an autosomal‐dominant proliferative
disorder characterized by erythrocytosis and hypersensitivity of erythroid progenitors to …

Erythrocytosis is a rare disorder characterized by increased red cell mass and elevated
hemoglobin concentration and hematocrit. Several genetic variants have been identified as …

We describe presenting features, treatment strategies, and follow‐up events involving 41
patients (median age 39 years, range 1–81; 54% males) with high oxygen affinity (HOA) …

Objective–The purposes of this study were to evaluate the oxygen affinity of hemoglobin
(Hb) in healthy retired racing Greyhounds via cooximetry, and to establish reference …

High oxygen-affinity haemoglobins (Hb) are among the earliest recognised molecular
defects in patients with inherited forms of erythrocytosis, and several α-globin and β-globin …

We present a case of a mother and daughter who were initially diagnosed with
polycythaemia vera and treated with venesectio. As JAK2 V6217F/exon 12 mutation …

Hb Johnstown [β109 (G11) Val→ Leu, G TG> T TG] has previously been described as a high
oxygen affinity variant in a heterozygous state and in combination with β0-thalassemia (β0 …

Hemoglobin (Hb) variants are genetic variations in the globin genes that code for an
abnormal globin protein structure and represent the world's most frequently found …