Mechanisms of cognitive dysfunction in CKD
Cognitive impairment is an increasingly recognized major cause of chronic disability and is
commonly found in patients with chronic kidney disease (CKD). Knowledge of the …
commonly found in patients with chronic kidney disease (CKD). Knowledge of the …
[HTML][HTML] Recent advances in urinary peptide and proteomic biomarkers in chronic kidney disease: a systematic review
Biomarker development, improvement, and clinical implementation in the context of kidney
disease have been a central focus of biomedical research for decades. To this point, only …
disease have been a central focus of biomedical research for decades. To this point, only …
[HTML][HTML] The first knock-in rat model for glutaric aciduria type I allows further insights into pathophysiology in brain and periphery
MG Melo, N Remacle, HP Cudré-Cung, C Roux… - Molecular Genetics and …, 2021 - Elsevier
Glutaric aciduria type I (GA-I, OMIM# 231670) is an inborn error of metabolism caused by a
deficiency of glutaryl-CoA dehydrogenase (GCDH). Patients develop acute encephalopathic …
deficiency of glutaryl-CoA dehydrogenase (GCDH). Patients develop acute encephalopathic …
[HTML][HTML] Proteomic analysis of mucopolysaccharidosis IIIB mouse brain
Mucopolysaccharidosis IIIB (MPS IIIB) is an inherited metabolic disease due to deficiency of
α-N-Acetylglucosaminidase (NAGLU) enzyme with subsequent storage of undegraded …
α-N-Acetylglucosaminidase (NAGLU) enzyme with subsequent storage of undegraded …
[HTML][HTML] Exploring key challenges of understanding the pathogenesis of kidney disease in Bardet–Biedl syndrome
Bardet–Biedl syndrome (BBS) is a rare pleiotropic inherited disorder known as a ciliopathy.
Kidney disease is a cardinal clinical feature; however, it is one of the less investigated traits …
Kidney disease is a cardinal clinical feature; however, it is one of the less investigated traits …
[HTML][HTML] Disentangling the relationship between chronic kidney disease and cognitive disorders
DM Kelly, PM Rothwell - Frontiers in Neurology, 2022 - frontiersin.org
Chronic kidney disease (CKD) is a rapidly rising global health burden that affects nearly
40% of older adults. Epidemiologic data suggest that individuals at all stages of chronic …
40% of older adults. Epidemiologic data suggest that individuals at all stages of chronic …
[HTML][HTML] Proteomic and bioinformatic investigation of altered pathways in neuroglobin-deficient breast cancer cells
Neuroglobin (NGB) is a myoglobin-like monomeric globin that is involved in several
processes, displaying a pivotal redox-dependent protective role in neuronal and extra …
processes, displaying a pivotal redox-dependent protective role in neuronal and extra …
[HTML][HTML] Combining robust urine biomarkers to assess chronic kidney disease progression
F Bienaimé, M Muorah, M Metzger, M Broeuilh… - …, 2023 - thelancet.com
Background Urinary biomarkers may improve the prediction of chronic kidney disease
(CKD) progression. Yet, data reporting the applicability of most commercial biomarker …
(CKD) progression. Yet, data reporting the applicability of most commercial biomarker …
[HTML][HTML] Multi-Omics Studies Unveil Extraciliary Functions of BBS10 and Show Metabolic Aberrations Underlying Renal Disease in Bardet–Biedl Syndrome
E Marchese, M Caterino, R Fedele, F Pirozzi… - International Journal of …, 2022 - mdpi.com
Bardet–Biedl syndrome (BBS) is a rare autosomal recessive ciliopathy resulting in multiple
organ dysfunctions, including chronic kidney disease (CKD). Despite the recent progress in …
organ dysfunctions, including chronic kidney disease (CKD). Despite the recent progress in …
[HTML][HTML] Label-free quantitative proteomics in a methylmalonyl-CoA mutase-silenced neuroblastoma cell line
Methylmalonic acidemias (MMAs) are inborn errors of metabolism due to the deficient
activity of methylmalonyl-CoA mutase (MUT). MUT catalyzes the formation of succinyl-CoA …
activity of methylmalonyl-CoA mutase (MUT). MUT catalyzes the formation of succinyl-CoA …