Inflammation and DNA damage: cause, effect or both
Inflammation is a biological response involving immune cells, blood vessels and mediators
induced by endogenous and exogenous stimuli, such as pathogens, damaged cells or …
induced by endogenous and exogenous stimuli, such as pathogens, damaged cells or …
NAD metabolism: Role in senescence regulation and aging
The geroscience hypothesis proposes that addressing the biology of aging could directly
prevent the onset or mitigate the severity of multiple chronic diseases. Understanding the …
prevent the onset or mitigate the severity of multiple chronic diseases. Understanding the …
CD38 mediates lung fibrosis by promoting alveolar epithelial cell aging
Rationale: A prevailing paradigm recognizes idiopathic pulmonary fibrosis (IPF) originating
from various alveolar epithelial cell (AEC) injuries, and there is a growing appreciation of …
from various alveolar epithelial cell (AEC) injuries, and there is a growing appreciation of …
The CD38 glycohydrolase and the NAD sink: implications for pathological conditions
JD Zeidler, KA Hogan, G Agorrody… - … of Physiology-Cell …, 2022 - journals.physiology.org
Nicotinamide adenine dinucleotide (NAD) acts as a cofactor in several oxidation-reduction
(redox) reactions and is a substrate for a number of nonredox enzymes. NAD is fundamental …
(redox) reactions and is a substrate for a number of nonredox enzymes. NAD is fundamental …
CD38 in SLE CD4 T cells promotes Ca2+ flux and suppresses interleukin-2 production by enhancing the expression of GM2 on the surface membrane
E Katsuyama, M Humbel, A Suarez-Fueyo… - Nature …, 2024 - nature.com
CD38 has emerged as a potential therapeutic target for patients with systemic lupus
erythematosus (SLE) but it is not known whether CD38 alters CD4+ T cell function. Using …
erythematosus (SLE) but it is not known whether CD38 alters CD4+ T cell function. Using …
Roles of NAD+ in Acute and Chronic Kidney Diseases
Nicotinamide adenine dinucleotide (oxidized form, NAD+) is a critical coenzyme, with
functions ranging from redox reactions and energy metabolism in mitochondrial respiration …
functions ranging from redox reactions and energy metabolism in mitochondrial respiration …
SARS-CoV-2 infection dysregulates NAD metabolism
A Izadpanah, JC Mudd, JGN Garcia… - Frontiers in …, 2023 - frontiersin.org
Introduction Severe COVID-19 results initially in pulmonary infection and inflammation.
Symptoms can persist beyond the period of acute infection, and patients with Post-Acute …
Symptoms can persist beyond the period of acute infection, and patients with Post-Acute …
New promising drugs for the treatment of systemic sclerosis: pathogenic considerations, enhanced classifications, and personalized medicine
A Lescoat, J Varga, M Matucci-Cerinic… - Expert opinion on …, 2021 - Taylor & Francis
ABSTRACT Introduction: Systemic sclerosis (SSc), also known as scleroderma, is a complex
orphan disease characterized by early inflammatory features, vascular hyper-reactivity, and …
orphan disease characterized by early inflammatory features, vascular hyper-reactivity, and …
NADH/NAD+ Redox Imbalance and Diabetic Kidney Disease
LJ Yan - Biomolecules, 2021 - mdpi.com
Diabetic kidney disease (DKD) is a common and severe complication of diabetes mellitus. If
left untreated, DKD can advance to end stage renal disease that requires either dialysis or …
left untreated, DKD can advance to end stage renal disease that requires either dialysis or …
[PDF][PDF] Senescent cells accumulate in systemic sclerosis skin
Systemic sclerosis (SSc) is characterized by intractable fibrosis in the skin and internal
organs. A unifying paradigm across all forms of fibrosis is transformation of quiescent …
organs. A unifying paradigm across all forms of fibrosis is transformation of quiescent …