Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy

G Sloan, D Selvarajah, S Tesfaye - Nature Reviews Endocrinology, 2021 - nature.com
Diabetic sensorimotor peripheral neuropathy (DSPN) is a serious complication of diabetes
mellitus and is associated with increased mortality, lower-limb amputations and distressing …

Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets

S Dewanjee, S Das, AK Das, N Bhattacharjee… - European journal of …, 2018 - Elsevier
Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …

Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy

NE Cameron, SEM Eaton, MA Cotter, S Tesfaye - Diabetologia, 2001 - Springer
Diabetes mellitus is a major cause of peripheral neuropathy, commonly manifested as distal
symmetrical polyneuropathy. This review examines evidence for the importance of vascular …

Metabolic and vascular factors in the pathogenesis of diabetic neuropathy

NE Cameron, MA Cotter - Diabetes, 1997 - Am Diabetes Assoc
Reduced nerve perfusion is an important factor in the etiology of diabetic neuropathy.
Studies in streptozotocin-induced diabetic rats show that nerve conduction velocity (NCV) …

[HTML][HTML] Diabetic painful and insensate neuropathy: pathogenesis and potential treatments

IG Obrosova - Neurotherapeutics, 2009 - Elsevier
Advanced peripheral diabetic neuropathy (PDN) is associated with elevated vibration and
thermal perception thresholds that progress to sensory loss and degeneration of all fiber …

Effect of angiotensin-converting-enzyme (ACE) inhibitor trandolapril on human diabetic neuropathy: randomised double-blind controlled trial

RA Malik, S Williamson, C Abbott, AL Carrington… - The Lancet, 1998 - thelancet.com
Background Diabetes is a common cause of polyneuropathy. The development and
progression of nephropathy, retinopathy, and neuropathy are closely related. Angiotensin …

The epidemiology of diabetic neuropathy

JE Shaw, PZ Zimmet - Diabetes Review, 1999 - research.monash.edu
The understanding of the epidemiology of diabetic peripheral neuropathy has been made
difficult by methodological issues relating to many of the published studies. Inconsistency in …

Arterio-venous shunting and proliferating new vessels in acute painful neuropathy of rapid glycaemic control (insulin neuritis)

S Tesfaye, R Malik, N Harris, JJ Jakubowski, C Mody… - diabetologia, 1996 - Springer
Insulin neuritis, or painful neuropathy following rapid improvement in glycaemic control, is
well recognised but its aetiology is unclear. An understanding of the processes involved in …

Hypertension as a risk factor for diabetic neuropathy: a prospective study

KYZ Forrest, RE Maser, G Pambianco, DJ Becker… - Diabetes, 1997 - Am Diabetes Assoc
The pathogeneses of diabetic neuropathy is still unclear. This study prospectively
investigated the risk factors for distal symmetrical polyneuropathy (DSP) in a cohort of …

Hypertension contributes to neuropathy in patients with type 1 diabetes

G Ponirakis, IN Petropoulos, U Alam… - American journal of …, 2019 - academic.oup.com
BACKGROUND Diabetic peripheral neuropathy (DPN) can lead to foot ulceration and
amputation. There are currently no disease-modifying therapies for DPN. The aim of this …