Agmatine, an endogenous polyamine derived from L-arginine, elicits tremendous
multimodal neuromodulant properties. Alterations in agmatinergic signalling are closely …

Major depressive disorder (MDD) is a disabling and highly prevalent mood disorder as well
as a common cause of suicide. Chronic stress, inflammation, and intestinal dysbiosis have …

Background and Aim. Depression is a social problem with high economic burden in the
society. Finding an effective agent with high efficacy and few side effects is therefore …

Healthy aging is an ambitious aspiration for humans, but neurodegenerative disorders, such
as Alzheimer's disease (AD), strongly affect quality of life. Using an integrated omics …

Agmatine (AGM), a naturally occurring polyamine derived from L-arginine, has shown
significant potential for neuroprotection in Parkinson's Disease (PD) due to its multifaceted …

ADHD is a highly prevalent neurodevelopmental disorder. The first-line therapeutic for
ADHD, methylphenidate, can cause serious side effects including weight loss, insomnia …

Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disorder
characterized by abnormal accumulation of extracellular β-amyloid (Aβ) plaques and …

Shifts in the magnitude and nature of gut microbial metabolites have been implicated in
Alzheimer's disease (AD), but the host receptors that sense and respond to these …

Abstracts Agmatine is a biogenic amine synthesized following decarboxylation of L-arginine
by the enzyme arginine decarboxylase and exhibits favourable outcome in …

Introduction: Studies have suggested dexmedetomidine (DEX) as a potential
antidepressant. However, no relevant research exists on its effects and mechanisms in …