Biobanks facilitate genome-wide association studies (GWASs), which have mapped
genomic loci across a range of human diseases and traits. However, most biobanks are …

Meta-analysis is pervasively used to combine multiple genome-wide association studies
(GWASs). Fine-mapping of meta-analysis studies is typically performed as in a single-cohort …

Polygenic risk scores (PRSs) have been widely explored in precision medicine. However,
few studies have thoroughly investigated their best practices in global populations across …

Primary open-angle glaucoma (POAG), the leading cause of irreversible blindness
worldwide, disproportionately affects individuals of African ancestry. We conducted a …

Genomics-driven drug discovery is indispensable for accelerating the development of novel
therapeutic targets. However, the drug discovery framework based on evidence from …

Elevated intraocular pressure (IOP) is influenced by environmental and genetic factors.
Increased IOP is a major risk factor for most types of glaucoma, including primary open …

Background: Age is the principal risk factor for neurodegeneration in both the retina and
brain. The retina and brain share many biological properties; thus, insights into retinal aging …

Glaucoma is in the top five age-related eye disorders with increasing prevalence globally.
Past research has led to the understanding of glaucoma as a neurodegenerative disease …

Meta-analysis is pervasively used to combine multiple genome-wide association studies
(GWASs). Finemapping of meta-analysis studies is typically performed as in a single-cohort …

Identifying causal variants for complex traits is a major goal of human genetics research.
Despite the great success of genome-wide association studies (GWAS) in locus discovery …