Cancer cells undergo metabolic alterations to meet the immense demand for energy,
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …

Most solid tumor cells adapt to their heterogeneous microenvironment by depending largely
on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which …

Mammalian tissues are fuelled by circulating nutrients, including glucose, amino acids, and
various intermediary metabolites. Under aerobic conditions, glucose is generally assumed …

Metastasis requires cancer cells to undergo metabolic changes that are poorly understood,–
. Here we show that metabolic differences among melanoma cells confer differences in …

Glycolysis has long been considered as the major metabolic process for energy production
and anabolic growth in cancer cells. Although such a view has been instrumental for the …

The high metabolic demand of cancer cells leads to an accumulation of H+ ions in the
tumour microenvironment. The disorganized tumour vasculature prevents an efficient wash …

In recent years there has been a growing interest among cancer biologists in cancer
metabolism. This Review summarizes past and recent advances in our understanding of the …

Cancer is a leading cause of death in many countries around the world. However, the
efficacy of current standard treatments for a variety of cancers is suboptimal. First, most …

Cancer-associated fibroblasts (CAFs) are a major cellular component of tumor
microenvironment in most solid cancers. Altered cellular metabolism is a hallmark of cancer …

The mitochondrial pyruvate dehydrogenase complex (PDC) irreversibly decarboxylates
pyruvate to acetyl coenzyme A, thereby linking glycolysis to the tricarboxylic acid cycle and …