The emergence of hematopoietic progenitors and their differentiation into various highly
specialized blood cell types constitute a finely tuned process. Unveiling the genetic …

The differentiation from multipotent hematopoietic stem cells (HSC) to mature and functional
blood cells requires the finely tuned regulation of gene expression at each stage of …

Reconstruction of the molecular pathways controlling organ development has been
hampered by a lack of methods to resolve embryonic progenitor cells. Here we describe a …

T-cell acute lymphoblastic leukemia (T-ALL) is a hematological malignancy characterized by
the clonal proliferation of immature T-cell precursors. T-ALL has many similar …

Highlights•Many oncogenes and tumor suppressors in T-ALL are transcription factors that
are required for normal hematopoiesis.•TAL1 induces a stem cell-like core transcriptional …

The generation of in vivo repopulating hematopoietic cells from in vitro differentiating
embryonic stem cells has remained a long-standing challenge. To date, hematopoietic …

TAL1/SCL is one of the most prevalent oncogenes in T-cell acute lymphoblastic leukemia (T-
ALL). TAL1 and its regulatory partners (GATA3, RUNX1, and MYB) positively regulate each …

Hematopoiesis is fully dependent on hematopoietic stem cells (HSCs) that possess the
capacity to self-renew and differentiate into all blood cell lineages. WASH, Wiskott–Aldrich …

Low oxygen and temperature pose key physiological challenges for endotherms living on
the Qinghai–Tibetan Plateau (QTP). Molecular adaptations to high‐altitude living have been …

Background: Mesp1 and Etv2 are essential transcription factors in the regulation of
mesodermal lineage development, but their relationship is unclear. Results: Mesp1 interacts …