The nuclear factor kappa B (NFκB) family of transcription factors is a key regulator of immune
development, immune responses, inflammation, and cancer. The NFκB signaling system …

The non-canonical NF-κB pathway is an important arm of NF-κB signaling that
predominantly targets activation of the p52/RelB NF-κB complex. This pathway depends on …

NF-κB was first described as a B-cell-specific transcription factor that binds the κB site in the
Ig κ light chain enhancer. Soon after, NF-κB activity was found to be inducible in all cell types …

Two distinct nuclear factor κB (NFκB) signaling pathways have been described; the
canonical pathway that mediates inflammatory responses, and the non-canonical pathway …

Signal transduction pathways are modular composites of functionally interdependent sets of
proteins that act in a coordinated fashion to transform environmental information into a …

Over the past few years, the transcription factor nuclear factor (NF)‐κB and the proteins that
regulate it have emerged as a signaling system of pre‐eminent importance in human …

The nuclear factor (NF)-κB pathway is important for the expression of a wide variety of genes
that are involved in the control of the host immune and inflammatory response, and in the …

Two members of the NF-κB (nuclear factor κB)/Rel transcription factor family, NF-κB1 and NF-
κB2, are produced as precursor proteins, NF-κB1 p105 and NF-κB2 p100 respectively …

Transcription factors of the NF-κB family regulate hundreds of genes in the context of
multiple important physiological and pathological processes. NF-κB activation depends on …

Atherosclerosis is an inflammatory disease, characterized by the accumulation of
macrophage-derived foam cells in the vessel wall and accompanied by the production of a …