Dopamine, immunity, and disease
B Channer, SM Matt, EA Nickoloff-Bybel, V Pappa… - Pharmacological …, 2023 - ASPET
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …
regulating many processes including reward, movement, and cognition. Dopamine also …
The reservoir of latent HIV
J Chen, T Zhou, Y Zhang, S Luo, H Chen… - Frontiers in cellular …, 2022 - frontiersin.org
The persistence of latent reservoir of the human immunodeficiency virus (HIV) is currently
the major challenge in curing HIV infection. After HIV infects the human body, the latent HIV …
the major challenge in curing HIV infection. After HIV infects the human body, the latent HIV …
The structural basis of accelerated host cell entry by SARS‐CoV‐2
M Seyran, K Takayama, VN Uversky… - The FEBS …, 2021 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the causative agent of
the pandemic coronavirus disease 2019 (COVID‐19) that exhibits an overwhelming …
the pandemic coronavirus disease 2019 (COVID‐19) that exhibits an overwhelming …
Intact HIV proviruses persist in the brain despite viral suppression with ART
CR Cochrane, TA Angelovich, SJ Byrnes… - Annals of …, 2022 - Wiley Online Library
Objective Human immunodeficiency virus (HIV) persistence in blood and tissue reservoirs,
including the brain, is a major barrier to HIV cure and possible cause of comorbid disease …
including the brain, is a major barrier to HIV cure and possible cause of comorbid disease …
The potential role of HIV-1 latency in promoting neuroinflammation and HIV-1-associated neurocognitive disorder
Despite potent suppression of HIV-1 viral replication in the central nervous system (CNS) by
antiretroviral therapy (ART), between 15% and 60% of HIV-1-infected patients receiving ART …
antiretroviral therapy (ART), between 15% and 60% of HIV-1-infected patients receiving ART …
HIV infection of non-classical cells in the brain
A Wahl, L Al-Harthi - Retrovirology, 2023 - Springer
HIV-associated neurological disorders (HAND) affect up to 50% of people living with HIV
(PLWH), even in the era of combination antiretroviral therapy (cART). HIV-DNA can be …
(PLWH), even in the era of combination antiretroviral therapy (cART). HIV-DNA can be …
Characterization of HIV-1 infection in microglia-containing human cerebral organoids
SBH Gumbs, A Berdenis van Berlekom, R Kübler… - Viruses, 2022 - mdpi.com
The achievement of an HIV cure is dependent on the eradication or permanent silencing of
HIV-latent viral reservoirs, including the understudied central nervous system (CNS) …
HIV-latent viral reservoirs, including the understudied central nervous system (CNS) …
Astrocytes are HIV reservoirs in the brain: a cell type with poor HIV infectivity and replication but efficient cell‐to‐cell viral transfer
S Valdebenito, P Castellano, D Ajasin… - Journal of …, 2021 - Wiley Online Library
The major barrier to eradicating Human immunodeficiency virus‐1 (HIV) infection is the
generation of tissue‐associated quiescent long‐lasting viral reservoirs refractory to therapy …
generation of tissue‐associated quiescent long‐lasting viral reservoirs refractory to therapy …
Identification, quantification, and characterization of HIV-1 reservoirs in the human brain
M Donoso, D D'Amico, S Valdebenito, CA Hernandez… - Cells, 2022 - mdpi.com
The major barrier to cure HIV infection is the early generation and extended survival of HIV
reservoirs in the circulation and tissues. Currently, the techniques used to detect and …
reservoirs in the circulation and tissues. Currently, the techniques used to detect and …
Expression of SARS-CoV-2-related receptors in cells of the neurovascular unit: implications for HIV-1 infection
Background Neurological complications are common in patients affected by COVID-19 due
to the ability of SARS-CoV-2 to infect brains. While the mechanisms of this process are not …
to the ability of SARS-CoV-2 to infect brains. While the mechanisms of this process are not …