Glioblastomas are the most common form of malignant primary brain tumor and an important
cause of morbidity and mortality. In recent years there have been important advances in …

Targeted anticancer drugs block cancer cell growth by interfering with specific signaling
pathways vital to carcinogenesis and tumor growth rather than harming all rapidly dividing …

We explored the clinical and pathological impact of epidermal growth factor receptor (EGFR)
extracellular domain missense mutations. Retrospective assessment of 260 de novo …

Eighty percent of all malignant primary brain tumors diagnosed in the United States are
gliomas. 1 The current treatment paradigm for high-grade gliomas (grades III and IV) …

Glioblastoma (GBM) is the most common and lethal intracranial malignancy, with few
advances in treatment over the last several decades. Much excitement surrounded the initial …

Magnetic resonance imaging is integral to the care of patients with high-grade gliomas.
Anatomic detail can be acquired with conventional structural imaging, but newer …

Background Amide proton transfer (APT) MRI has the potential to demonstrate antitumor
effects by reflecting biologically active tumor portion, providing different information from …

Background In the current study, we pooled imaging data in newly diagnosed glioblastoma
(GBM) patients from international multicenter clinical trials, single institution databases, and …

Simple Summary Conventional magnetic resonance imaging (MRI) sequences have known
limitations in target delineation for radiation treatment (RT) planning of cerebral gliomas …

Precision medicine promises better healthcare delivery by improving clinical practice. Using
evidence-based substratification of patients, the objective is to achieve better prognosis …