Risk-based treatment approaches for neuroblastoma have been ongoing for decades.
However, the criteria used to define risk in various institutional and cooperative groups were …

Neuroblastoma (NB), the most common extracranial tumor of childhood, is a cancer of
primordial neural crest cells that give rise to sympathetic neural ganglia and adrenal …

Background Gene expression profiling is being widely applied in cancer research to identify
biomarkers for clinical endpoint prediction. Since RNA-seq provides a powerful tool for …

Abstract Background Quantitative PCR (qPCR) aims to measure the DNA or RNA
concentration in diagnostic and biological samples based on the quantification cycle (Cq) …

Neuroblastoma is an embryonal malignancy of the sympathetic nervous system.
Spontaneous regression and differentiation of neuroblastoma is observed in a subset of …

Neuroblastoma is a pediatric tumor of the sympathetic nervous system. MYCN (V-myc
myelocytomatosis viral-related oncogene, neuroblastoma derived [avian]) is amplified in …

RNA transcripts such as mRNA or microRNA are frequently used as biomarkers to
determine disease state or response to therapy. Reverse transcription (RT) in combination …

Myc proteins (c-myc, Mycn and Mycl) target proliferative and apoptotic pathways vital for
progression in cancer. Amplification of the MYCN gene has emerged as one of the clearest …

Compromised RNA quality is suggested to lead to unreliable results in gene expression
studies. Therefore, assessment of RNA integrity and purity is deemed essential prior to …

Background Neuroblastoma is characterized by substantial clinical heterogeneity. Despite
intensive treatment, the survival rates of high-risk neuroblastoma patients are still …