Rare but recurrent mutations in the fibroblast growth factor receptor (FGFR) pathways, most
commonly in one of the four FGFR receptor tyrosine kinase genes, can potentially be …

Synthetic lethality is a genetic interaction that results in cell death when two genetic
deficiencies co-occur but not when either deficiency occurs alone, which can be co-opted for …

Fusions of two genes can lead to the generation of chimeric RNAs, which may have a
distinct functional role from their original molecules. Chimeric RNAs could encode novel …

There is limited guidance on exploiting the genome‐wide loss‐of‐function CRISPR screens
in cancer Dependency Map (DepMap) to identify new targets for individual cancer types …

The diversity of structural variants (SVs) in melanoma and how they impact oncogenesis are
incompletely known. We performed harmonized analysis of SVs across melanoma histologic …

Cancer dependency maps have accelerated the discovery of tumor vulnerabilities that can
be exploited as drug targets when translatable to patients. The Cancer Genome Atlas …

Aberrant alternative polyadenylation (APA) events play an important role in cancers, but little
is known about whether APA-related genetic variants contribute to the susceptibility to …

Simple Summary Genomic amplifications are highly prevalent in cancer and often contribute
to increased proliferation or cell survival upon the administration of anti-cancer drugs. The …

Biliary tract cancers (BTCs) are a group of deadly malignancies encompassing intrahepatic
and extrahepatic cholangiocarcinoma, gallbladder carcinoma, and ampullary carcinoma …

Large-scale multidimensional cancer genomic and pharmacological profiles have been
created by several large consortium projects, including NCI-60, GDSC and DepMap …