The emerging role of mass spectrometry-based proteomics in drug discovery

F Meissner, J Geddes-McAlister, M Mann… - Nature Reviews Drug …, 2022 - nature.com
Proteins are the main targets of most drugs; however, system-wide methods to monitor
protein activity and function are still underused in drug discovery. Novel biochemical …

Artificial intelligence in cancer target identification and drug discovery

Y You, X Lai, Y Pan, H Zheng, J Vera, S Liu… - … and Targeted Therapy, 2022 - nature.com
Artificial intelligence is an advanced method to identify novel anticancer targets and discover
novel drugs from biology networks because the networks can effectively preserve and …

Therapeutic target database update 2022: facilitating drug discovery with enriched comparative data of targeted agents

Y Zhou, Y Zhang, X Lian, F Li, C Wang… - Nucleic acids …, 2022 - academic.oup.com
Drug discovery relies on the knowledge of not only drugs and targets, but also the
comparative agents and targets. These include poor binders and non-binders for developing …

Utilizing graph machine learning within drug discovery and development

T Gaudelet, B Day, AR Jamasb, J Soman… - Briefings in …, 2021 - academic.oup.com
Graph machine learning (GML) is receiving growing interest within the pharmaceutical and
biotechnology industries for its ability to model biomolecular structures, the functional …

Artificial intelligence in drug discovery: applications and techniques

J Deng, Z Yang, I Ojima, D Samaras… - Briefings in …, 2022 - academic.oup.com
Artificial intelligence (AI) has been transforming the practice of drug discovery in the past
decade. Various AI techniques have been used in many drug discovery applications, such …

Improving target assessment in biomedical research: the GOT-IT recommendations

CH Emmerich, LM Gamboa, MCJ Hofmann… - Nature reviews Drug …, 2021 - nature.com
Academic research plays a key role in identifying new drug targets, including understanding
target biology and links between targets and disease states. To lead to new drugs, however …

[HTML][HTML] Integrative multi-omics approaches in cancer research: from biological networks to clinical subtypes

YJ Heo, C Hwa, GH Lee, JM Park, JY An - Molecules and cells, 2021 - Elsevier
Multi-omics approaches are novel frameworks that integrate multiple omics datasets
generated from the same patients to better understand the molecular and clinical features of …

Mass spectrometry‐based high‐throughput proteomics and its role in biomedical studies and systems biology

CB Messner, V Demichev, Z Wang, J Hartl… - …, 2023 - Wiley Online Library
There are multiple reasons why the next generation of biological and medical studies
require increasing numbers of samples. Biological systems are dynamic, and the effect of a …

Sprouts and microgreens: Trends, opportunities, and horizons for novel research

A Galieni, B Falcinelli, F Stagnari, A Datti, P Benincasa - Agronomy, 2020 - mdpi.com
Sprouts and microgreens have attracted tremendous interest across multiple disciplines in
recent years. Here, we critically review the most recent advances to underscore research …

Unrealized targets in the discovery of antibiotics for gram-negative bacterial infections

U Theuretzbacher, B Blasco, M Duffey… - Nature Reviews Drug …, 2023 - nature.com
Advances in areas that include genomics, systems biology, protein structure determination
and artificial intelligence provide new opportunities for target-based antibacterial drug …