Alkenes and their derivatives are featured widely in a variety of natural products,
pharmaceuticals, and advanced materials. Significant efforts have been made toward the …

Transition metal-catalyzed direct functionalization of C–H bonds is one of the key emerging
strategies that is currently attracting tremendous attention with the aim to provide alternative …

Olefinic C–H functionalization represents an atom-and step economic approach to valuable
olefin derivatives from simpler ones, but controlling the selectivity remains a challenge …

Transition metal-catalyzed directed C–H activation has emerged as an increasingly powerful
tool for the synthesis of important organic building blocks, organic materials and natural …

Conspectus The history of transition metal catalysis is heavily steeped in ligand design,
clearly demonstrating the importance of this approach. The intimate relationship between …

Rapid progress in the fields of organometallic chemistry and homogeneous catalysis has
made it possible for synthetic chemists to consider using ubiquitous yet unreactive C–H …

The use of directing groups has proven to be a successful strategy to enhance reactivity and
control selectivity in C–H functionalization reactions. In the past decade, a multitude of new …

Over the last several decades, researchers have achieved remarkable progress in the field
of organometallic chemistry. The development of metal-catalyzed cross-coupling reactions …

Once considered the “holy grail” of organometallic chemistry, synthetically useful reactions
employing CH bond activation have increasingly been developed and applied to natural …

An external-oxidant-free process to access the isoquinolone motif via cross-
coupling/cyclization of benzhydroxamic acid with alkynes is described. The reaction features …