Cellular imaging using stimulated Raman scattering microscopy

AH Hill, D Fu - Analytical chemistry, 2019 - ACS Publications
Cellular imaging is an active area of research that enables researchers to monitor cellular
dynamics, as well as responses to various external stimuli (physiological stress, exogenous …

Rise of Raman spectroscopy in neurosurgery: a review

D DePaoli, É Lemoine, K Ember… - … of biomedical optics, 2020 - spiedigitallibrary.org
Significance: Although the clinical potential for Raman spectroscopy (RS) has been
anticipated for decades, it has only recently been used in neurosurgery. Still, few devices …

The role of altered lipid composition and distribution in liver fibrosis revealed by multimodal nonlinear optical microscopy

H Jia, J Liu, T Fang, Z Zhou, R Li, W Yin, Y Qian… - Science …, 2023 - science.org
Intracellular lipid accumulation is commonly seen in fibrotic livers, but its exact role in liver
fibrosis remains elusive. Here, we established a multimodal nonlinear optical microscopy to …

Higher-order coherent anti-Stokes Raman scattering microscopy realizes label-free super-resolution vibrational imaging

L Gong, W Zheng, Y Ma, Z Huang - Nature Photonics, 2020 - nature.com
Coherent Raman scattering (for example, coherent anti-Stokes Raman scattering (CARS)
and stimulated Raman scattering) microscopy has emerged as a powerful tool for label-free …

[HTML][HTML] Advances in stimulated Raman scattering imaging for tissues and animals

L Shi, AA Fung, A Zhou - Quantitative imaging in medicine and …, 2021 - ncbi.nlm.nih.gov
Stimulated Raman scattering (SRS) microscopy has emerged in the last decade as a
powerful optical imaging technology with high chemical selectivity, speed, and subcellular …

Stimulated Raman scattering tomography enables label‐free volumetric deep tissue imaging

L Gong, S Lin, Z Huang - Laser & Photonics Reviews, 2021 - Wiley Online Library
A novel z‐scan‐free stimulated Raman scattering tomography (SRST) is presented which is
enabled by using optical beating technique (OBT) associated with Bessel beams to achieve …

Cancer surgery 2.0: guidance by real-time molecular technologies

N Ogrinc, P Saudemont, Z Takats, M Salzet… - Trends in Molecular …, 2021 - cell.com
In vivo cancer margin delineation during surgery remains a major challenge. Despite the
availability of several image guidance techniques and intraoperative assessment, clear …

Saturated stimulated-Raman-scattering microscopy for far-field superresolution vibrational imaging

L Gong, W Zheng, Y Ma, Z Huang - Physical Review Applied, 2019 - APS
Stimulated Raman-scattering (SRS) microscopy has emerged as a powerful tool for
quantitative vibrational imaging of live tissues and cells with biochemical specificity, but the …

Tracking the differentiation status of human neural stem cells through label-free Raman spectroscopy and machine learning-based analysis

J Geng, W Zhang, C Chen, H Zhang, A Zhou… - Analytical …, 2021 - ACS Publications
The ability to noninvasively monitor stem cells' differentiation is important to stem cell
studies. Raman spectroscopy is a non-harmful imaging approach that acquires the cellular …

[HTML][HTML] Real-time monitoring of pharmacokinetics of antibiotics in biofilms with Raman-tagged hyperspectral stimulated Raman scattering microscopy

K Bae, W Zheng, Y Ma, Z Huang - Theranostics, 2019 - ncbi.nlm.nih.gov
Antibiotics resistance developed by biofilms has posed a clinical challenge in the effective
treatment of bacterial infections. However, the resistance mechanisms have not been well …