Many cancers possess the ability to suppress the immune response to malignant cells, thus
facilitating tumour growth and invasion, and this has fuelled research to reverse these …

We have shown that KRAS–TP53 genomic coalteration is associated with immune-excluded
microenvironments, chemoresistance, and poor survival in pancreatic ductal …

Advances in cancer immunotherapy, particularly immune checkpoint inhibitors, have
dramatically improved the prognosis for patients with metastatic melanoma and other …

We report the results of 24 women, 50%(N= 12) with hormone receptor-positive breast
cancer and 50%(N= 12) with advanced triple-negative breast cancer, treated with …

Inside the tumor microenvironment, a complicated immunosuppressive network is
constituted by tumor cells and suppressive immune cells as its nodes, including myeloid …

Background The precise characterization of individual tumors and immune
microenvironments using transcriptome sequencing has provided a great opportunity for …

Pleural mesothelioma (PM) is characterized by poor prognosis and limited therapeutic
options. Y-box-binding protein 1 (YB-1) was shown to drive growth and migration of PM …

Myeloid‐derived suppressor cells (MDSCs) are an immature group of myeloid‐derived cells
generated from myeloid cell precursors in the bone marrow. MDSCs appear almost …

Nucleolar and spindle-associated protein 1 (NUSAP1) is a microtubule-associated protein
that plays a crucial role in mitosis. Despite initial reports suggesting a potential involvement …

Triple-negative breast cancer (TNBC) is a unique subtype of breast cancer characterized by
the lack of expression of the estrogen receptor, progesterone receptor, and human …