Prefrontal interneurons: populations, pathways, and plasticity supporting typical and disordered cognition in rodent models
Prefrontal cortex (PFC) inhibitory microcircuits regulate the gain and timing of pyramidal
neuron firing, coordinate neural ensemble interactions, and gate local and long-range …
neuron firing, coordinate neural ensemble interactions, and gate local and long-range …
Shared mechanisms of GABAergic and opioidergic transmission regulate corticolimbic reward systems and cognitive aspects of motivational behaviors
The functional interplay between the corticolimbic GABAergic and opioidergic systems plays
a crucial role in regulating the reward system and cognitive aspects of motivational …
a crucial role in regulating the reward system and cognitive aspects of motivational …
Dynorphin/kappa-opioid receptor regulation of excitation-inhibition balance toggles afferent control of prefrontal cortical circuits in a pathway-specific manner
The medial prefrontal cortex (mPFC) controls behavior via connections with limbic excitatory
afferents that engage various inhibitory motifs to shape mPFC circuit function. The dynorphin …
afferents that engage various inhibitory motifs to shape mPFC circuit function. The dynorphin …
Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction
Restless legs syndrome (RLS) affects up to 10% of older adults. Their healthcare is impeded
by delayed diagnosis and insufficient treatment. To advance disease prediction and find …
by delayed diagnosis and insufficient treatment. To advance disease prediction and find …
Opioid modulation of prefrontal cortex cells and circuits
RH Cole, K Moussawi, ME Joffe - Neuropharmacology, 2024 - Elsevier
Several neurochemical systems converge in the prefrontal cortex (PFC) to regulate cognitive
and motivated behaviors. A rich network of endogenous opioid peptides and receptors …
and motivated behaviors. A rich network of endogenous opioid peptides and receptors …
Neuropeptide inactivation regulates egg-laying behavior to influence reproductive health in Caenorhabditis elegans
JY Lo, KM Adam, JL Garrison - Current Biology, 2024 - cell.com
Neural communication requires both fast-acting neurotransmitters and neuromodulators that
function on slower timescales to communicate. Endogenous bioactive peptides, often called" …
function on slower timescales to communicate. Endogenous bioactive peptides, often called" …
[HTML][HTML] Substance P, NPY, CCK and their receptors in five brain regions in major depressive disorder with transcriptomic analysis of locus coeruleus neurons
Major depressive disorder (MDD) is a serious disease and a burden to patients, families and
society. Rodent experiments and human studies suggest that several neuropeptide systems …
society. Rodent experiments and human studies suggest that several neuropeptide systems …
Neuropeptide signaling is required to implement a line attractor encoding a persistent internal behavioral state
Internal states drive survival behaviors, but their neural implementation is not well
understood. Recently we identified a line attractor in the ventromedial hypothalamus (VMH) …
understood. Recently we identified a line attractor in the ventromedial hypothalamus (VMH) …
Transient receptor potential ankyrin 1 ion channel expressed by the Edinger-Westphal nucleus contributes to stress adaptation in murine model of posttraumatic stress …
The centrally projecting Edinger-Westphal nucleus (EWcp) is involved in stress adaptation.
Transient receptor potential ankyrin 1 (TRPA1) mRNA was previously shown to be …
Transient receptor potential ankyrin 1 (TRPA1) mRNA was previously shown to be …
Sex differences in brain region-specific activation of c-Fos following kappa opioid receptor stimulation or acute stress in mice
Q Ma, S Wonnacott, SJ Bailey, CP Bailey - International Journal of …, 2023 - mdpi.com
Kappa opioid receptors (KOPr) are involved in the response to stress. KOPr are also targets
for the treatment of stress-related psychiatric disorders including depression, anxiety, and …
for the treatment of stress-related psychiatric disorders including depression, anxiety, and …