Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

Genetically encoded biosensors based on fluorescent proteins (FPs) are a reliable tool for
studying the various biological processes in living systems. The circular permutation of …

Abstract cAMP is a key second messenger that regulates diverse cellular functions including
neural plasticity. However, the spatiotemporal dynamics of intracellular cAMP in intact …

Cyclic adenosine monophosphate (cAMP) signaling integrates information from diverse G-
protein-coupled receptors, such as neuromodulator receptors, to regulate pivotal biological …

Opsins form a family of light-activated, retinal-dependent, G protein-coupled receptors
(GPCRs) that serve a multitude of visual and nonvisual functions. Opsin 3 (OPN3 or …

In order to analyze how a signal transduction network converts cellular inputs into cellular
outputs, ideally one would measure the dynamics of many signals within the network …

Cyclic adenosine monophosphate (cAMP) is a universal second messenger that plays a
crucial role in diverse biological functions, ranging from transcription to neuronal plasticity …

Studies over the past two decades have demonstrated that astrocytes are tightly associated
with neurons and play pivotal roles in neural circuit development, operation, and adaptation …

Compartmentalization of cellular signaling forms the molecular basis of cellular behavior.
The primary cilium constitutes a subcellular compartment that orchestrates signal …

Signaling networks are spatiotemporally organized in order to sense diverse inputs, process
information, and carry out specific cellular tasks. In pancreatic β cells, Ca 2+, cyclic …