Although the structure of lipoic acid and its role in bacterial metabolism were clear over 50
years ago, it is only in the past decade that the pathways of biosynthesis of this universally …

SUMMARY Lipoic acid [(R)-5-(1, 2-dithiolan-3-yl) pentanoic acid] is an enzyme cofactor
required for intermediate metabolism in free-living cells. Lipoic acid was discovered nearly …

Biological microscopy would benefit from smaller alternatives to green fluorescent protein for
imaging specific proteins in living cells. Here we introduce PRIME (PRobe Incorporation …

The greatest potential environmental benefit of metabolic engineering would be the
production of high-volume commodity chemicals, such as biofuels. Yet, the high yields …

Recent studies have revealed that mitochondria are able to synthesize fatty acids in a
malonyl-CoA/acyl carrier protein (ACP)-dependent manner. This pathway resembles …

Abstract Background and Aims The increased frequency of urinary tract infections in patients
with primary biliary cholangitis (PBC) and the cross‐reactivity between the lipoyl domains …

Lipoic acid is a sulfur-containing cofactor required for the function of several multienzyme
complexes involved in the oxidative decarboxylation of α-keto acids and glycine …

Two vitamins, biotin and lipoic acid, are essential in all three domains of life. Both
coenzymes function only when covalently attached to key metabolic enzymes. There they …

Escherichia coli lipoic acid ligase (LplA) catalyzes ATP-dependent covalent ligation of lipoic
acid onto specific lysine side chains of three acceptor proteins involved in oxidative …

The efficacy of melatonin, glutathione, serotonin, minocycline, lipoic acid and ascorbic acid
in counteracting the toxicity of paraquat in Drosophila melanogaster was examined. Male …