Lipids play a diverse and critical role in cellular processes in all tissues. The unique lipid
composition of nerve membranes is particularly interesting because it contains, among other …

Computational techniques applied to drug discovery have gained considerable popularity
for their ability to filter potentially active drugs from inactive ones, reducing the time scale …

Inhibitors of heterotrimeric G proteins are being developed as therapeutic agents.
Epitomizing this approach are YM-254890 (YM) and FR900359 (FR), which are efficacious …

A surprisingly clear picture of the allosteric mechanism connecting G protein-coupled
receptor agonists with G protein binding—and back–is revealed by a puzzle of thirty novel …

Simple Summary Gap junction channels are composed of an assembly of connexin proteins
and allow direct communication between cells. They are highly conserved across …

Background and Purpose The dopamine D2 receptor is expressed as a short (D2S) and a
long (D2L) isoform with 29 additional amino acids in the third intracellular loop. The D2S …

G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors, with
many GPCRs having crucial roles in endocrinology and metabolism. Cryogenic electron …

G protein‐coupled receptors (GPCRs) are one of the major drug targets. In recent years,
computational drug design for GPCRs has mainly focused on static structures obtained …

A recent report from the Skiniotis group, 1 published in Nature, provides fascinating insight
into the molecular choreography underlying a quintessential cellular signaling mechanism …

Orexin 2 receptor (OX2R) is a G protein-coupled receptor (GPCR) whose activation is crucial
to regulation of the sleep-wake cycle. Recently, inactive and active state structures were …