In dividing cells, chromosome duplication once per generation must be coordinated with
faithful segregation of newly replicated chromosomes and with cell growth and division …

From microbes to multicellular eukaryotic organisms, all cells contain pathways responsible
for genome maintenance. DNA replication allows for the faithful duplication of the genome …

Chromosomes of a broad range of species, from bacteria to mammals, are structured by
large topological domains whose precise functional roles and regulatory mechanisms …

The organization of the Escherichia coli chromosome has been defined genetically as
consisting of four insulated macrodomains and two less constrained regions. Here we have …

In many bacteria, there is a genome-wide bias towards co-orientation of replication and
transcription, with essential and/or highly-expressed genes further enriched co-directionally …

Whole-genome sequencing is a powerful technique for obtaining the reference sequence
information of multiple organisms. Its use can be dramatically expanded to rapidly identify …

Bacteria thrive in virtually all environments. Like all other living organisms, bacteria may
encounter various types of stresses, to which cells need to adapt. In this chapter, we …

Integrative and conjugative elements (ICEs), aka conjugative transposons, are mobile
genetic elements involved in many biological processes, including pathogenesis, symbiosis …

DNA replication is tightly controlled to ensure accurate inheritance of genetic information. In
all organisms, initiator proteins possessing AAA+ (ATPases associated with various cellular …

In many bacteria, there is a strong bias for genes to be encoded on the leading strand of
DNA, resulting in coorientation of replication and transcription. In Bacillus subtilis …