Atopic dermatitis: pathophysiology
The pathophysiology of atopic dermatitis is complex and multifactorial, involving elements of
barrier dysfunction, alterations in cell mediated immune responses, IgE mediated …
barrier dysfunction, alterations in cell mediated immune responses, IgE mediated …
The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis
T Dainichi, A Kitoh, A Otsuka, S Nakajima… - Nature …, 2018 - nature.com
The skin provides both a physical barrier and an immunologic barrier to external threats. The
protective machinery of the skin has evolved to provide situation-specific responses to …
protective machinery of the skin has evolved to provide situation-specific responses to …
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
JS Ried, J Li, XB Zuo, XD Zheng, XY Yin, LD Sun… - Nature …, 2015 - nature.com
Genetic association studies have identified 21 loci associated with atopic dermatitis risk
predominantly in populations of European ancestry. To identify further susceptibility loci for …
predominantly in populations of European ancestry. To identify further susceptibility loci for …
[HTML][HTML] Efficacy and safety of lebrikizumab (an anti-IL-13 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical …
Background Interleukin (IL)-13 plays a key role in type 2 inflammation and is an emerging
pathogenic mediator in atopic dermatitis (AD). Objective We investigated the efficacy and …
pathogenic mediator in atopic dermatitis (AD). Objective We investigated the efficacy and …
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Reduced glomerular filtration rate defines chronic kidney disease and is associated with
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …
BSACI guideline for the diagnosis and management of allergic and non‐allergic rhinitis (Revised Edition 2017; 2007)
GK Scadding, HH Kariyawasam… - Clinical & …, 2017 - Wiley Online Library
This is an updated guideline for the diagnosis and management of allergic and non‐allergic
rhinitis, first published in 2007. It was produced by the Standards of Care Committee of the …
rhinitis, first published in 2007. It was produced by the Standards of Care Committee of the …
JAKs and STATs in immunity, immunodeficiency, and cancer
JAKs and STATs in Immunity, Immunodeficiency, and Cancer | NEJM Skip to main content
NEJM Group Follow Us Facebook Twitter Instagram YouTube LinkedIn Prepare to become a …
NEJM Group Follow Us Facebook Twitter Instagram YouTube LinkedIn Prepare to become a …
[PDF][PDF] JAK and STAT signaling molecules in immunoregulation and immune-mediated disease
The discovery of the Janus kinase (JAK)-signal transducer and activator of transcripton
(STAT) signaling pathway, a landmark in cell biology, provided a simple mechanism for …
(STAT) signaling pathway, a landmark in cell biology, provided a simple mechanism for …
Atopic dermatitis: immune deviation, barrier dysfunction, IgE autoreactivity and new therapies
M Furue, T Chiba, G Tsuji, D Ulzii… - Allergology …, 2017 - jstage.jst.go.jp
abstract Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely
pruritic skin disorder mostly associated with IgE elevation and skin barrier dysfunction due to …
pruritic skin disorder mostly associated with IgE elevation and skin barrier dysfunction due to …