Liver X receptors (LXRs) are master regulators of cholesterol homeostasis and inflammation
in the central nervous system (CNS). The brain, which contains a disproportionately large …

The present review describes the transgenic mouse models that have been designed to
evaluate the functions of the cytochrome P450s involved in cholesterol and bile acid …

Abnormalities in neuronal cholesterol homeostasis have been suspected or observed in
several neurodegenerative disorders including Alzheimer's disease, Parkinson's disease …

Huntington's disease is an autosomal dominant neurodegenerative disease caused by
abnormal polyglutamine expansion in huntingtin (Exp-HTT) leading to degeneration of …

Huntington's disease (HD) is an autosomal dominant genetic disorder caused by an
expansion of the CAG repeat in the first exon of Huntingtin's gene. The associated …

The development of Alzheimer's disease (AD) is influenced by several events, among which
the dysregulation of cholesterol metabolism in the brain plays a major role. Maintenance of …

Oxysterols are oxidized 27-carbon cholesterol derivatives or by-products of cholesterol
biosynthesis, with a spectrum of biologic activities. Several oxysterols have cytotoxic and pro …

The brain-specific enzyme CYP46A1 controls cholesterol turnover by converting cholesterol
into 24 S-hydroxycholesterol (24OH). Dysregulation of brain cholesterol turnover and …

Oxysterols are cholesterol metabolites generated in the liver and other peripheral tissues as
a mechanism of removing excess cholesterol. Oxysterols have a wide range of biological …

The adult brain exhibits a characteristic cholesterol homeostasis, with low synthesis rate and
active catabolism. Brain cholesterol turnover is possible thanks to the action of the enzyme …