Objective The repair of cartilaginous lesions within synovial joints is still an unresolved and
weighty clinical problem. Although research activity in this area has been indefatigably …

Although the field of gene delivery is dominated by viral vectors and synthetic polymeric or
lipid gene carriers, natural polymers offer distinct advantages and may help advance the …

Caused by the DNA monkeypox virus belonging to the orthopoxvirus genus and transmitted
between animals and humans and from human to human, monkeypox disease results in …

Injuries to the musculoskeletal system are common, debilitating and expensive. In many
cases, healing is imperfect, which leads to chronic impairment. Gene transfer might improve …

Hyaline articular cartilage, the load-bearing tissue of the joint, has very limited repair and
regeneration capacities. The lack of efficient treatment modalities for large chondral defects …

The goal of tissue engineering is the production of functional, biocompatible tissues by
seeding cells within biological or synthetic scaffolds. One tissue engineering approach …

Osteoarthritis (OA) is a prevalent, disabling disorder of the joints that affects a large
population worldwide and for which there is no definitive cure. This review provides critical …

Adapting controlled release technologies to the delivery of DNA has the potential to
overcome extracellular barriers that limit gene therapy. Controlled release systems can …

Bone tissue engineering, gene therapy based on human mesenchymal stem cells (MSCs)
and silk fibroin biomaterials were combined to study the impact of viral transfection on MSC …

Gene delivery to bone is useful both as an experimental tool and as a potential therapeutic
strategy. Among its advantages over protein delivery are the potential for directed, sustained …