The present paper considers recent progress in our understanding of the afferent/ascending
neural pathways and neural circuits of interoception. Of particular note is the extensive role …

Omnivores, including rodents and humans, compose their diets from a wide variety of
potential foods. Beyond the guidance of a few basic orosensory biases such as attraction to …

Given the crucial role of the gastrointestinal tract and associated organs in handling nutrient
assimilation and metabolism, it has long been known that its communication with the brain is …

Enteroendocrine cells (EECs) in both invertebrates and vertebrates derive from intestinal
stem cells (ISCs) and are scattered along the digestive tract, where they function in sensing …

Background The gut-brain axis, which mediates the bi-directional communication between
the gastrointestinal system and the central nervous system (CNS), plays a fundamental role …

The development of new tools to interface with the nervous system, empowered by
advances in electronics and materials science, has transformed neuroscience and is …

Whole-body health relies on complex inter-organ signalling networks that enable organisms
to adapt to environmental perturbations and to changes in tissue homeostasis. The intestine …

Feeding behavior is guided by multiple competing physiological needs, as animals must
sense their internal nutritional state and then identify and consume foods that meet …

One of the distinctive features of the human taste system is that it categorizes food into a few
taste qualities–eg, sweet, salty, sour, bitter, and umami. Here, I examined the functional …

Appropriate food intake requires exquisite coordination between the gut and the brain.
Indeed, it has long been known that gastrointestinal signals communicate with the brain to …