[HTML][HTML] From molecules to genomic variations: Accelerating genome analysis via intelligent algorithms and architectures

M Alser, J Lindegger, C Firtina, N Almadhoun… - Computational and …, 2022 - Elsevier
We now need more than ever to make genome analysis more intelligent. We need to read,
analyze, and interpret our genomes not only quickly, but also accurately and efficiently …

GenStore: A high-performance in-storage processing system for genome sequence analysis

N Mansouri Ghiasi, J Park, H Mustafa, J Kim… - Proceedings of the 27th …, 2022 - dl.acm.org
Read mapping is a fundamental step in many genomics applications. It is used to identify
potential matches and differences between fragments (called reads) of a sequenced …

SeGraM: A universal hardware accelerator for genomic sequence-to-graph and sequence-to-sequence mapping

DS Cali, K Kanellopoulos, J Lindegger… - Proceedings of the 49th …, 2022 - dl.acm.org
A critical step of genome sequence analysis is the mapping of sequenced DNA fragments
(ie, reads) collected from an individual to a known linear reference genome sequence (ie …

A framework for high-throughput sequence alignment using real processing-in-memory systems

S Diab, A Nassereldine, M Alser, J Gómez Luna… - …, 2023 - academic.oup.com
Motivation Sequence alignment is a memory bound computation whose performance in
modern systems is limited by the memory bandwidth bottleneck. Processing-in-memory …

GenStore: A High-Performance and Energy-Efficient In-Storage Computing System for Genome Sequence Analysis

NM Ghiasi, J Park, H Mustafa, J Kim, A Olgun… - arXiv preprint arXiv …, 2022 - arxiv.org
Read mapping is a fundamental, yet computationally-expensive step in many genomics
applications. It is used to identify potential matches and differences between fragments …

Gmx: Instruction set extensions for fast, scalable, and efficient genome sequence alignment

M Doblas, O Lostes-Cazorla, Q Aguado-Puig… - Proceedings of the 56th …, 2023 - dl.acm.org
Sequence alignment remains a fundamental problem in computer science with practical
applications ranging from pattern matching to computational biology. The ever-increasing …

WFA-FPGA: An efficient accelerator of the wavefront algorithm for short and long read genomics alignment

A Haghi, S Marco-Sola, L Alvarez… - Future Generation …, 2023 - Elsevier
In the last years, advances in genome sequencing technologies have enabled the
proliferation of genomic applications that guide personalized medicine. These applications …

Machine learning for agile fpga design

D Pal, C Deng, E Ustun, C Yu, Z Zhang - Machine Learning Applications in …, 2022 - Springer
Field-programmable gate arrays (FPGAs) have become popular means of hardware
acceleration since they offer massive parallelism, flexible configurability, and potentially …

Genpip: In-memory acceleration of genome analysis via tight integration of basecalling and read mapping

H Mao, M Alser, M Sadrosadati, C Firtina… - 2022 55th IEEE/ACM …, 2022 - ieeexplore.ieee.org
Nanopore sequencing is a widely-used high-throughput genome sequencing technology
that can sequence long fragments of a genome into raw electrical signals at low cost …

Accelerating edit-distance sequence alignment on GPU using the wavefront algorithm

Q Aguado-Puig, S Marco-Sola, JC Moure… - IEEE …, 2022 - ieeexplore.ieee.org
Sequence alignment remains a fundamental problem with practical applications ranging
from pattern recognition to computational biology. Traditional algorithms based on dynamic …