Immunity and inflammation in atherosclerosis

D Wolf, K Ley - Circulation research, 2019 - Am Heart Assoc
There is now overwhelming experimental and clinical evidence that atherosclerosis is a
chronic inflammatory disease. Lessons from genome-wide association studies, advanced in …

T cell subsets and functions in atherosclerosis

R Saigusa, H Winkels, K Ley - Nature Reviews Cardiology, 2020 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall and the primary
underlying cause of cardiovascular disease. Data from in vivo imaging, cell-lineage tracing …

The immunology of atherosclerosis

A Gisterå, GK Hansson - Nature reviews nephrology, 2017 - nature.com
Cardiovascular disease is the leading cause of death worldwide, both in the general
population and among patients with chronic kidney disease (CKD). In most cases, the …

The role of infiltrating immune cells in dysfunctional adipose tissue

TJ Guzik, DS Skiba, RM Touyz… - Cardiovascular …, 2017 - academic.oup.com
Adipose tissue (AT) dysfunction, characterized by loss of its homeostatic functions, is a
hallmark of non-communicable diseases. It is characterized by chronic low-grade …

Inflammation resolution: implications for atherosclerosis

AC Doran - Circulation research, 2022 - Am Heart Assoc
Resolution is an active and highly coordinated process that occurs in response to
inflammation to limit tissue damage and promote repair. When the resolution program fails …

[HTML][HTML] Cytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets

DP Ramji, TS Davies - Cytokine & growth factor reviews, 2015 - Elsevier
Atherosclerosis, a chronic inflammatory disorder of the arteries, is responsible for most
deaths in westernized societies with numbers increasing at a marked rate in developing …

The role of cytokines in the development of atherosclerosis

AR Fatkhullina, IO Peshkova, EK Koltsova - Biochemistry (Moscow), 2016 - Springer
Atherosclerosis contributes to the development of many cardiovascular diseases, which
remain the leading cause of death in developed countries. Atherosclerosis is a chronic …

Regulatory T cells in cardiovascular diseases

X Meng, J Yang, M Dong, K Zhang, E Tu… - Nature Reviews …, 2016 - nature.com
Inflammation is essential in the initial development and progression of many cardiovascular
diseases involving innate and adaptive immune responses. The role of CD4+ CD25+ …

Inflammation in atherosclerosis: from pathophysiology to practice

P Libby, PM Ridker, GK Hansson… - Journal of the American …, 2009 - jacc.org
Until recently, most envisaged atherosclerosis as a bland arterial collection of cholesterol,
complicated by smooth muscle cell accumulation. According to that concept, endothelial …

Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction

G Zizzo, BA Hilliard, M Monestier… - The Journal of …, 2012 - journals.aai.org
Mer tyrosine kinase (MerTK) is a major macrophage apoptotic cell (AC) receptor. Its
functional impairment promotes autoimmunity and atherosclerosis, whereas overexpression …