Low grade gliomas are the most frequent brain tumors in children and encompass a
spectrum of histologic entities which are currently assigned World Health Organisation …

Recent advances in genomic technology have led to a better understanding of key
molecular alterations that underlie glioblastoma (GBM). The current WHO-based …

We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse
intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of> …

Diffuse intrinsic pontine glioma (DIPG) is the most severe paediatric solid tumour, with no
significant therapeutic progress made in the past 50 years. Recent studies suggest that …

Pediatric high-grade glioma (HGG) is a devastating disease with a less than 20% survival
rate 2 years after diagnosis. We analyzed 127 pediatric HGGs, including diffuse intrinsic …

Diffuse intrinsic pontine gliomas (DIPGs) are incurable childhood brainstem tumors with
frequent histone H3 K27M mutations and recurrent alterations in PDGFRA and TP53. We …

Glioblastoma (GBM) is a brain tumor that carries a dismal prognosis and displays
considerable heterogeneity. We have recently identified recurrent H3F3A mutations affecting …

High-grade gliomas in children are different from those that arise in adults. Recent
collaborative molecular analyses of these rare cancers have revealed previously …

To identify somatic mutations in pediatric diffuse intrinsic pontine glioma (DIPG), we
performed whole-genome sequencing of DNA from seven DIPGs and matched germline …

Gliomas are the most common CNS tumors in children and adolescents, and they show an
extremely broad range of clinical behavior. The majority of pediatric gliomas present as …