Mitochondria ensure the supply of cellular energy through the production of ATP via
oxidative phosphorylation. The alteration of this process, called mitochondrial dysfunction …

Elevated mitochondrial matrix superoxide and/or hydrogen peroxide concentrations drive a
wide range of physiological responses and pathologies. Concentrations of superoxide and …

Excessive mitochondrial ROS production has been causally linked to the pathophysiology of
aging in the heart and other organs, and plays a deleterious role in several age-related …

Healthy aging is the art of balancing a delicate scale. On one side of the scale, there are the
factors that make life difficult with aging, and on the other side are the products of human …

Mitochondria provide energy to the cell during aerobic respiration by supplying~ 95% of the
adenosine triphosphate (ATP) molecules via oxidative phosphorylation. These organelles …

Cardiovascular diseases (CVDs) are the leading cause of deaths worldwide with regulated
cell death playing an important role in cardiac pathophysiology. However, the classical …

Curcumin is well known as a potent antioxidant and free radical scavenger and has great
potential for anti-aging applications. In this study, we investigate the molecular mechanism …

Zinc plays an important role in cardiomyocytes, where it exists in bound and histochemically
reactive labile Zn2+ forms. Although Zn2+ concentration is under tight control through …

We have previously demonstrated that placental 11β-hydroxysteroid dehydrogenase type 2
(11β-HSD2) dysfunction contributes to PE pathogenesis. We sought to elucidate molecular …

Cardiac dysfunction in heart failure (HF) and diabetic cardiomyopathy (DCM) is associated
with aberrant intracellular Ca2+ handling and impaired mitochondrial function accompanied …