Chronic wasting disease (CWD) is a unique transmissible spongiform encephalopathy
(TSE) of mule deer (Odocoileus hemionus), white-tailed deer (O. virginianus), and Rocky …

The inherited platelet disorders are an uncommon cause of symptomatic bleeding. They
may be difficult to diagnose (and are likely to be under‐diagnosed) and pose problems in …

The indications for transfusing fresh‐frozen plasma (FFP), cryoprecipitate and
cryosupernatant plasma are very limited. When transfused they can have unpredictable …

Summary Background Variant Creutzfeldt-Jakob disease (vCJD) is a novel human prion
disease caused by infection with the agent of bovine spongiform encephalopathy (BSE) …

A critical concern in the transmission of prion diseases, including chronic wasting disease
(CWD) of cervids, is the potential presence of prions in body fluids. To address this issue …

Bacterial contamination of transfusion products, especially platelets, is a longstanding
problem that has been partially controlled through modern phlebotomy practices …

The once heretical concept that a misfolded protein is the infectious agent responsible for
prion diseases is now widely accepted. Recent exciting research has led not only to the end …

Some of the most prevalent human degenerative diseases appear as a result of the
misfolding and aggregation of proteins. Compelling evidence suggest that misfolded protein …

Cell membrane microparticles (MPs) circulate in the blood of healthy donors, and their
elevated counts have been documented in various pathologies. Microparticles are …

Although the risk of transfusion-transmitted infections today is lower than ever, the supply of
safe blood products remains subject to contamination with known and yet to be identified …