Active pharmaceutical ingredients (APIs) extracted and isolated from traditional Chinese
medicines (TCMs) are of interest for drug development due to their wide range of biological …

The design and synthesis of pharmaceutical cocrystals have received great interest in the
recent years. Cocrystallization of drug substances offers a tremendous opportunity for the …

Co-crystallization is one of the methods to enhance the solubility of hydrophobic drugs that
belong to BCS class II. Preparation and characterization of atorvastatin calcium co-crystals …

In development of new product major constraints are poor aqueous solubility and low oral
bioavailability. Crystallization is one the approach has been used for enhancement of …

Ritonavir is a BCS class II antiretroviral agent which shows poor aqueous solubility and low
oral bioavailability. The cocrystallization approach was selected to overcome these …

Many active ingredients from traditional Chinese medicine (TCM) exhibit poor
pharmaceutical properties (eg, low aqueous solubility, slow dissolution, low bioavailability …

Purpose: To enhance the dissolution rate of the poorly soluble drug atorvastatin calcium
(ATC) by cocrystallization with selected coformers. Enhancement of the dissolution rate and …

Yeast glucan particles are porous polysaccharide cell walls extracted from Saccharomyces
cerevisiae. Being mildly immunogenic, they are efficiently phagocytosed and have therefore …

Pharmaceutical cocrystal is one of solid-state modification for drug substance, mainly for
solubility improvement. Traditionally, cocrystal can be prepared by solvent evaporation …

Oxyresveratrol (ORV) is a naturally extracted compound with many pharmacological
activities. However, information about the crystalline form is not known when considering the …