Since the earliest findings of Otto Warburg, who discovered the first metabolic differences
between lactate production of cancer cells and non-malignant tissues in the 1920s, much …

Simple Summary Although the dysfunction of the succinate dehydrogenase complex in
mitochondria leads to cancer and other diseases due to aberrant metabolic reactions and …

The oxidative tricarboxylic acid (TCA) cycle is a central mitochondrial pathway integrating
catabolic conversions of NAD+ to NADH and anabolic production of aspartate, a key amino …

Mitochondria are critical organelles that provide energy as ATP to the cell. Besides 37 genes
encoded by mitochondrial genome, it has been estimated that over 1500 nuclear genes are …

Background: Enzymes of tricarboxylic acid (TCA) have recently been recognized as tumor
suppressors. Mutations in the SDHB subunit of succinate dehydrogenase (SDH) cause …

To meet the anabolic demands of the proliferative potential of tumor cells, malignant cells
tend to rewire their metabolic pathways. Although different types of malignant cells share this …

Simple Summary Though gastrointestinal stromal tumor is the most common mesenchymal
neoplasm of the gastrointestinal tract, it is a rare entity among pediatric patients. It is usually …

Hemangioblastomas (HBs) are highly vascularized, slow-growing, rare benigntumors (WHO
grade I). They account for about 2% of intracranialneoplasms; however, they are the most …

Pure mucinous breast carcinoma (PMBC) is characterized by clusters of tumor cells floating
in abundant extracellular mucin and can be classified into paucicellular (Type A) and …

Background: Mutations in genes encoding one of the subunits of succinate dehydrogenase
(SDH) are involved in pheochromocytoma (PHEO) and paraganglioma (PGL) development …